Effect of EIT-guided PEEP in ARDS Patients

Recruiting now · Not applicable

Conditions studied: ARDS (Acute Respiratory Distress Syndrome)

In brief

Acute respiratory syndrome distress (ARDS) is a clinical common syndrome with high mortality. Mechanical ventilation (MV) is the cornerstone of management of ARDS but can lead to ventilator-induced lung injury. Positive end-expiratory pressure (PEEP), as one of main component of MV, has been widely used in the clinical practice. However, the PEEP selection is still a difficult problem for moderate to severe ARDS patients. EIT, an imaging tool evaluating the regional ventilation distribution at the bedside, can achieve the individual PEEP selection for all mechanically ventilated patients. Our previous study found that moderate to severe ARDS patients with higher recruitability could benefit from EIT-guided PEEP. This article compared the effect of PEEP titrated guided by EIT with fraction of inspired oxygen (FiO2)-PEEP table on the clinical outcomes in ARDS patients.

Key facts

Study ID

NCT06990477

Run by

Southeast University, China

People needed

2400

Starts

2026-03-13

Expected to finish

2030-02-20

Last updated by the study team

2026-07-10

Who can join

Age: 19 and older, up to 90. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age≥18 years
• Moderate-to-severe ARDS, defined by the ARDS Definition Task Force in the Berlin definition (partial pressure of arterial oxygen [PaO2]:FiO2 ratio ≤200 mmHg with a PEEP ≥5 cmH2O)
• Diagnosis of ARDS less than 72 hours

You may not qualify if…

• Expected to be mechanically ventilated for less than 48 hours
• Severe chronic respiratory diseases requiring long-term home oxygen therapy or noninvasive MV
• Undrained pneumothorax or subcutaneous emphysema
• Contraindication to the use of EIT (pacemaker, automatic implantable cardioverter defibrillator, and implantable pumps)
• Severe neuromuscular disease
• Hemodynamic instability
• Contraindications to hypercapnia, such as intracranial hypertension or acute coronary syndrome
• Severe other organs dysfunction with a low expected survival (7 days) or palliative care
• Severe liver disease (Child-Pugh Score ≥10)
• Pregnancy
• Refusal to sign the informed consent

Where it is running

• Department of Critical Care Medicine, Zhongshan Hospital of Fudan University — Shanghai, China Mainland, China (enrolling)
• Zhongda Hospital, School of Medicine, Southeast University — Nanjing, Jiangsu, China (enrolling)
• The First Affiliated Hospital of Guangzhou Medical University — Guangzhou, Guangdong, China
• Zhengzhou Central Hospital Affiliated to Zhengzhou University — Zhengzhou, Henan, China
• The Affiliated Hospital of Hangzhou Normal University — Hangzhou, Jiangsu, China
• The Affiliated Hospital of Xuzhou Medical University — Xuzhou, Jiangsu, China
• The First Affiliated Hospital of Nanchang University — Nanchang, Jiangxi, China
• Qinghai University Affiliated Hospital — Xining, Qinghai, China
• First Affiliated Hospital of Xi'an Jiaotong University — Xian, Shanxi, China
• People's Hospital of Quzhou — Quzhou, Zhejiang, China
• Affiliated Beijing Chaoyang Hospital of Capital Medical University — Beijing, China
• Run Run Shaw Hospital affiliated to Zhejiang University School of Medicine — Hangzhou, China
• Ruijin Hospital Shanghai Jiaotong University School Of Medicine — Shanghai, China
• Asan Medical Center — Seoul, South Korea
• Second Hospital of Anhui Medical University — Hefei, Anhui, China
• Taichung Veterans General Hospital — Taichung, Taiwan
• Department of Critical Care Medicine, Renji Hospital — Shanghai, China Mainland, China

Full record on ClinicalTrials.gov

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