A Study to Learn About the Medicine Ponsegromab in Adults With Cancer of the Pancreas Which Has Spread and Caused Significant Body Weight Loss and Fatigue

Recruiting now · Phase 2/Phase 3 · Has a placebo group

Conditions studied: Cachexia, Metastatic Pancreatic Ductal Adenocarcinoma

In brief

Study to investigate the efficacy, safety and tolerability of systemic chemotherapy plus ponsegromab versus systemic chemotherapy plus placebo for the first-line treatment in adult participants with cachexia and metastatic pancreatic ductal adenocardinoma.

Key facts

Study ID

NCT06989437

Run by

Pfizer

People needed

982

Starts

2025-10-03

Expected to finish

2029-12-10

Last updated by the study team

2026-07-09

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

Where it is running

• The University of Alabama at Birmingham — Birmingham, Alabama, United States (enrolling)
• The Kirklin Clinic of UAB Hospital — Birmingham, Alabama, United States (enrolling)
• Central Arkansas Radiation Therapy Institute, dba CARTI — Bryant, Arkansas, United States (enrolling)
• Central Arkansas Radiation Therapy Institute, dba CARTI — Conway, Arkansas, United States (enrolling)
• CARTI Cancer Center — Little Rock, Arkansas, United States (enrolling)
• Central Arkansas Radiation Therapy Institute, dba CARTI — North Little Rock, Arkansas, United States (enrolling)
• Central Arkansas Radiation Therapy Institute, dba CARTI — Pine Bluff, Arkansas, United States (enrolling)
• UC San Diego Medical Center - Encinitas — Encinitas, California, United States (enrolling)
• Chao Family Comprehensive Cancer Center and Ambulatory Care — Irvine, California, United States (enrolling)
• UCI Health - Irvine — Irvine, California, United States (enrolling)
• UC San Diego Koman Family Outpatient Pavilion — La Jolla, California, United States (enrolling)
• UC San Diego Medical Center - La Jolla (Jacobs Medical Center / Thornton Pavilion) — La Jolla, California, United States (enrolling)
• UC San Diego Moores Cancer Center — La Jolla, California, United States (enrolling)
• UC San Diego Sulpizio Cardiovascular Center — La Jolla, California, United States (enrolling)
• Cedars-Sinai Cancer at Cedars-Sinai Medical Center — Los Angeles, California, United States (enrolling)
• UCLA Department of Medicine - Hematology/Oncology — Los Angeles, California, United States (enrolling)
• UC Irvine Health — Orange, California, United States (enrolling)
• UC San Diego Medical Center - Bankers Hill — San Diego, California, United States (enrolling)
• UC San Diego McGrath Outpatient Pavilion - Hillcrest — San Diego, California, United States (enrolling)
• UC San Diego Medical Center - Hillcrest — San Diego, California, United States (enrolling)
• UC San Diego Medical Center - Rancho Bernardo — San Diego, California, United States (enrolling)
• UCLA Hematology/Oncology - Santa Monica — Santa Monica, California, United States (enrolling)
• Providence Medical Foundation — Santa Rosa, California, United States (enrolling)
• UC San Diego Medical Center - Vista — Vista, California, United States (enrolling)
• Georgetown University Medical Center - Department of Pharmacy, Oncology Pharmacy — Washington D.C., District of Columbia, United States (enrolling)

Full record on ClinicalTrials.gov

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