Lymphedema Prevention Through Immediate Lymphatic Reconstruction (LILY) Trial.

Recruiting now · Phase 2

Conditions studied: Lymphedema

In brief

To learn if reconstruction of the lymphatic system at the time of axillary lymphadenectomy can reduce the risk of developing lymphedema.

Key facts

Study ID

NCT06989099

Run by

M.D. Anderson Cancer Center

People needed

50

Starts

2024-09-24

Expected to finish

2029-08-01

Last updated by the study team

2026-02-19

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Participants diagnosed with IBC.
• Participants who have been scheduled for ILR/pLVB by their treating physician/surgeon at the time of their axillary lymphadenectomy for breast cancer
• Participants willing and able to comply with the study protocol requirements and all study-related visit requirements.
• Female subjects at least 18 years old and capable of providing consent to participate.
• Females of childbearing potential must have a negative urine pregnancy test within 36 hours prior to study drug administration and agree to use a medically accepted method of contraception for a period of one month following the study.

You may not qualify if…

• Patients known to be pregnant or breast-feeding.
• Patients with known or suspected iodine or ICG hypersensitivity.
• Patients unable to remain stationary for one hour.
• Active cellulitis.
• Subjects with a preoperative clinical lymphedema diagnosis.
• Subjects undergoing bilateral ALND.
• Subjects requiring immediate chest wall reconstruction with a pedicled or microvascular flap, or those that have received preoperative radiation therapy.
• Patients with BMI >45kg/m2.

Where it is running

• MD Anderson Cancer Center — Houston, Texas, United States (enrolling)

Full record on ClinicalTrials.gov

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