The Safety and Efficacy of Radiofrequency Ablation After Left Atrial Appendage Occlusion.

Recruiting now

Conditions studied: Cardiovascular Diseases, Arrhythmia

In brief

Objective: To evaluate the safety and efficacy of transcatheter atrial fibrillation ablation 1 month after WATCHMAN FLX left atrial appendage closure in patients with nonvalvular atrial fibrillation.

Key facts

Study ID

NCT06984731

Run by

Affiliated Hospital of Nantong University

People needed

210

Starts

2025-04-21

Expected to finish

2028-06-01

Last updated by the study team

2025-05-22

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• ≥18 years of age, diagnosed with nonvalvular atrial fibrillation;
• Meet the indications for receiving WATCHMAN FLX left atrial appendicular closure and transcatheter atrial fibrillation ablation;
• Preoperative imaging evaluation showed that the anatomical structure of the left atrial appendage was suitable for implantation with the WATCHMAN FLX device;
• The patient agrees to participate in the study and signs the informed consent.

You may not qualify if…

• valvular heart disease or other structural heart disease that causes atrial fibrillation;
• left auricular thrombus or acute thrombotic event was found before surgery;
• Patients with severe bleeding tendency or recent major bleeding events (such as massive gastrointestinal bleeding, cerebral hemorrhage, etc.);
• Patients who are unable to complete postoperative follow-up (such as life expectancy of less than 1 year or poor compliance);
• Other serious diseases (such as liver and kidney failure, active infection, etc.) were found in preoperative examination;
• Pregnant or lactating women.

Where it is running

• Affiliated hospital of Nantong University — Nantong, Jiangsu, China (enrolling)

Full record on ClinicalTrials.gov

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