Safe Effective Therapy With Low-Dose Glucocorticoid in ANCA-Associated Vasculitis (SAFE-LOW)
Recruiting now · Phase 3
Conditions studied: Granulomatosis With Polyangiitis, Microscopic Polyangiitis (MPA)
In brief
The purpose of this study is to determine the safety and efficacy of a therapeutic regimen consisting of 4 weeks of glucocorticoids given with a combination of the usual induction agents for ANCA-associated vasculitis. The trial will compare this regimen to the current standard of care treatment and glucocorticoid dosing for ANCA-associated vasculitis with severe kidney involvement. This trial will begin as a pilot to assess feasibility of recruitment and of adherence to the intervention.
Key facts
- Study ID
- NCT06983821
- Run by
- Ottawa Hospital Research Institute
- People needed
- 36
- Starts
- 2025-11-10
- Expected to finish
- 2029-02-01
- Last updated by the study team
- 2026-01-30
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- The Ottawa Hospital — Ottawa, Ontario, Canada (enrolling)
- St-Joseph's Hospital — Hamilton, Ontario, Canada
Full record on ClinicalTrials.gov
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