Randomized Trial Comparing Fecal Testing (FIT) to Colonoscopy for Post-polypectomy Surveillance

Recruiting now · Not applicable

Conditions studied: Colorectal Neoplasms

In brief

From observational studies, it is know that the risk of developing colorectal cancer after polyp removal is lower if the patients adheres to surveillance recommendations. However, colonoscopy is burdensome for patients and colonoscopy availability is limited in many parts of the world. In addition, more than half of surveillance colonoscopies are without any findings. The trial investigates whether surveillance using fecal testing for blod is as good as colonoscopy after removal of colorectal polyps.

Key facts

Study ID

NCT06983639

Run by

Sorlandet Hospital HF

People needed

4000

Starts

2026-01-09

Expected to finish

2050-01-01

Last updated by the study team

2026-01-15

Who can join

Age: 40 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• High-quality baseline colonoscopy with adequat cleansing and cecal intubation
• Remocval of at least one advanced adenoma
• Clean colon (all polyps removed)
• Signed informed consent

You may not qualify if…

• Colorectal cancer
• History of surgical colon resection for any reason
• Genetic cancer syndrome (adenomatous or serrated polyposis syndrome; Lynch or Lynch-like syndrome)
• ≥ 10 adenomas at baseline colonoscopy (cumulative)
• History of advanced serrated lesion, defined as SSL≥ 10mm or with dysplasia
• Inflammatory bowel disease
• On-going palliative care for any reason

Where it is running

• Sørlandet sykehus HF — Arendal, Agder, Norway (enrolling)

Full record on ClinicalTrials.gov

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