Atacicept in Multiple Glomerular Diseases
Recruiting now · Phase 2
Conditions studied: pMN, IgAN, Nephrotic Syndrome, MCD, FSGS
In brief
A study to find how well atacicept works and how safe it is in participants with autoimmune kidney disease.
Key facts
- Study ID
- NCT06983028
- Run by
- Vera Therapeutics, Inc.
- People needed
- 250
- Starts
- 2025-07-07
- Expected to finish
- 2027-11-01
- Last updated by the study team
- 2026-06-26
Who can join
Age: 2 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Weight of at least 40 kg
- On a stable prescribed standard of care (SoC) treatment regimen according to local guidelines and the specific requirements for each disease
- Systolic blood pressure ≤160 mmHg and diastolic blood pressure ≤90 mmHg at Screening.
- Diagnosis of IgAN, IgAVN, pMN, MCD, FSGS, or primary nephrotic syndrome
- For patients enrolling in IgAN cohorts (eligibility varies by cohort):
- Age ≥ 18 years
- Biopsy proven IgAN, IgAVN, or recurrent IgAN in kidney transplant
- UPCR ≥ 0.5 g/g or UPE ≥ 0.5 g/day on 24h urine
- eGFR≥ 20 mL/min/1.73m2
- For patients enrolling in pediatric IgAN Cohorts (eligibility varies by cohort):
- Age ≥ 2 years and < 18 years
- Biopsy proven IgAN or IgAVN
- On stable prescribed regimen of RAASi (or SoC) for at least 8 weeks
- UPCR ≥ 1.0 g/g or UPE ≥ 1.0 g/d on 24h urine
- eGFR≥ 30 mL/min/1.73m2
- For patients enrolling in pMN cohorts (eligibility varies by cohort):
- Age ≥ 18 years
- Biopsy-proven pMN
- Anti PLA2R antibodies ≥ 25 RU/mL
- UPCR ≥ 1.5 g/g or UPE ≥ 1.5 g/d on 24h urine
- At low risk for spontaneous remission (based on severity or duration of disease)
- For patients enrolling in Nephrotic Syndrome cohorts (MCD, FSGS, or pediatric idiopathic nephrotic syndrome):
- Age ≥ 10 years
- eGFR ≥30 mL/min/1.73m2
- Adults with biopsy diagnosis of primary MCD or FSGS (adults) or children with challenging clinical course with steroids (frequenlty relapsing, steroid-dependent, or steroid-resistant)
Where it is running
- Vera Therapeutics — Brisbane, California, United States (enrolling)
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.