Efficacy and Safety of Photodynamic Therapy for Cervical and Vaginal Intraepithelial Neoplasia

Recruiting now · Not applicable

Conditions studied: Precancerous Cervical Lesion

In brief

To investigate the efficacy and safety of photodynamic therapy (20% 5-amino-ketovalerate 630nm red light) in the treatment of cervical and vaginal intraepithelial neoplasia in women in the real world.

Key facts

Study ID

NCT06982976

Run by

Peking University Third Hospital

People needed

250

Starts

2025-02-28

Expected to finish

2028-12-31

Last updated by the study team

2025-05-21

Who can join

Age: 18 and older, up to 65. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• cervical/vaginal high-grade squamous intraepithelial lesions (HSILs) confirmed by colposcopy and pathological biopsy (CIN2 /CIN3 and/or VaIN2/ VaIN3) or persistent CIN1/VaIN1 lasting for more than one year with a strong willingness to treat;
• colposcopy was adequate, and analysable colposcopy images were retained;
• endocervical curettage (ECC) did not suggest higher-grade lesions.

You may not qualify if…

• coexistence or suspicion of cancer;
• porphyria or suspected allergies to red and blue light;
• severe medical comorbidities；

Where it is running

• Peking Unniversity Third Hospital — Beijing, Beijing Municipality, China (enrolling)

Full record on ClinicalTrials.gov

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