Minimum Time Effect of Fish Oil on Arterial Stiffness
Completed · Not applicable · Has a placebo group
Conditions studied: Arterial Stiffness
In brief
This study will seek to determine the minimum time of 4 g/day fish oil supplementation to cause a clinically significant effect on arterial stiffness. Accordingly, 30 moderately active, otherwise healthy adult subjects who are not currently taking any dietary supplementations will be recruited for the study. They will be randomized in a double-blind fashion into one of two groups: placebo group or fish oil dietary supplementation group. Subjects will either receive 4 g/day fish oil or placebo for 6 weeks. Each subject will undergo a series of baseline and follow-up tests including anthropometry, ultrasonography of the carotid artery, applanation tonometry, and blood pressure acquisition at week 0, 2, 4, and 6. Subjects will be required to maintain an activity and food log. Subjects will be asked to maintain their normal activity pattern during the study period. Repeated measures analysis of variance will be used to examine the effects of treatment and the treatment-order interaction on arterial stiffness (and other dependent variables).
Key facts
- Study ID
- NCT06981364
- Run by
- Salisbury University
- People needed
- 26
- Starts
- 2022-10-01
- Expected to finish
- 2023-01-05
- Last updated by the study team
- 2025-05-20
Who can join
Age: 18 and older, up to 30. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Age 18-30 yearsa,d
- Moderately active (exercise 3-5 days per week, >30 min per day)
- Weight stable for previous 6 months (>2.5 kg)
- Willing to be randomized to treatments and commit to all aspect of study
- Provide health history questionnaire and informed consent.
- Female subjects only- reported regular menstrual cycles for the last 2 years
You may not qualify if…
- BP>140/90
- Diabetes
- Familial hypercholesterolemia
- Past or current history of CHD, stroke or major CVD events. Respiratory diseases, endocrine or metabolic, neurological, or hematological disorders that would compromise the study or the health of the subject.
- Active renal or liver disease
- All medications that influence dependent variablesb
- Recent surgery
- Alcohol abusec
- Women must not be pregnant, plan to become pregnant during the study, or be nursing
- Claustrophobia
Where it is running
- Salisbury University — Salisbury, Maryland, United States
Full record on ClinicalTrials.gov
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