Dexmedetomidine, Magnesium Sulphate and Lidocaine for Cough Suppression After General Anesthesia

Recruiting now · Phase 3

Conditions studied: Cough

In brief

The aim of this prospective randomized controlled double-blinded study is to compare the efficacy of dexmedetomidine, MgSO4 and lidocaine for cough suppression during general anesthetic emergence as regard number and severity.

Key facts

Study ID

NCT06979141

Run by

Al-Azhar University

People needed

300

Starts

2025-06-02

Expected to finish

2026-08-01

Last updated by the study team

2025-06-11

Who can join

Age: 21 and older, up to 60. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Aged 21-60 years.
• Both genders.
• Body mass index < 30 kg/ m2
• American Society of Anesthesiology (ASA) physical status I-II.
• Mallampati score class I or II.
• Patients undergoing surgery under general anesthesia.

You may not qualify if…

• Known allergy to study drugs.
• History of psychiatric illness.
• Patients with major organ diseases.
• Pre-existing neurological deficits.
• Body mass index >30 kg/m2.
• Active airway infection or history of tracheal and laryngeal surgery.
• Lower esophageal sphincter incompetence (and reflux).
• Increased intracranial and intraocular pressure.
• Use of cough-inducing medications
• Pregnant, and lactating women.

Where it is running

• Faculty of Medicine, Al-Azhar university Assiut, Egypt. — Asyut, Egypt (enrolling)

Full record on ClinicalTrials.gov

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