Sleep TO Prevent Post-surgical Pain

Recruiting now · Not applicable

Conditions studied: Knee Osteoarthristis

In brief

This research study is being done to compare different methods of addressing sleep problems before total knee replacement surgery. These methods include Cognitive Behavioral Therapy and light exposure.

Key facts

Study ID

NCT06976138

Run by

Johns Hopkins University

People needed

252

Starts

2025-06-13

Expected to finish

2029-07-31

Last updated by the study team

2026-08-07

Who can join

Age: 60 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• People with knee osteoarthritis,
• 60 years old and older,
• scheduled to have unilateral (one knee) total knee replacement surgery for osteoarthritis and
• have trouble falling or staying asleep

You may not qualify if…

• currently using medications to help sleep
• have completed Cognitive Behavioral Therapy for Insomnia
• used either Bright Light or Negative Ion exposures in the past year
• have an inflammatory rheumatologic disorder, seizure disorder
• serious mental health disorder, Bipolar I disorder, substance or alcohol use disorder
• serious sleep or circadian rhythm disorder, untreated sleep apnea
• are pregnant or lactating
• have retinal pathology
• history of eye surgery (Lasik or cataract okay if more than 3 months ago)
• are taking disease-modifying antirheumatic drugs
• taking photosensitizing medications
• are unwilling to discontinue over the counter sleep aids (for example, melatonin) for at least 2 weeks before enrolling

Where it is running

• Johns Hopkins School of Medicine — Baltimore, Maryland, United States (enrolling)
• Mass General Brigham — Chestnut Hill, Massachusetts, United States

Full record on ClinicalTrials.gov

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