Dose Escalation Study With Bispecific Antibodies in Adult Participants With Lupus Nephritis
Recruiting now · Phase 1
Conditions studied: Lupus Nephritis (LN)
In brief
This study is researching a particular group of experimental drugs administered for a short period in the treatment of participants with Lupus Nephritis (LN). The main aim of the current study is to see how safe and tolerable the study drugs are in a long-term follow-up. This is a main study, called an umbrella study, which includes several independent smaller sub-studies. Each of these smaller main sub-studies tests different drugs at the same time, all aimed at treating LN. The study is looking at several other research questions, including: * What side effects may happen from taking the study drug * How much study drug is in the blood at different times * Whether the body makes antibodies against the study drug (which could make the drug less effective or could lead to side effects)
Key facts
- Study ID
- NCT06975787
- Run by
- Regeneron Pharmaceuticals
- People needed
- 90
- Starts
- 2025-12-22
- Expected to finish
- 2029-09-09
- Last updated by the study team
- 2026-07-09
Who can join
Age: 18 and older, up to 60. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Mayo Clinic — Rochester, Minnesota, United States (enrolling)
- Baylor College of Medicine — Houston, Texas, United States (enrolling)
- Centre Hospitalier Universitaire (CHU) Bordeaux — Bordeaux, New Aquitaine, France (enrolling)
- University Hospital Regensburg — Regensburg, Bavaria, Germany (enrolling)
- University Medical Center of the Johannes Gutenberg-University Mainz — Mainz, Germany (enrolling)
- Hallym University Sacred Heart Hospital — Anyang-si, Gyeonggi-do, South Korea (enrolling)
- Seoul National University Hospital — Seoul, South Korea (enrolling)
- Samsung Medical Center — Seoul, South Korea (enrolling)
- Yonsei University College of Medicine, Severance Hospital — Seoul, South Korea (enrolling)
- Hospital Universitario Virgen del Rocio — Seville, Andalusia, Spain (enrolling)
- Clinica Universidad de Navarra — Pamplona, Navarre, Spain (enrolling)
- Hospital Gregorio Maranon — Madrid, Spain (enrolling)
- Hospital Universitario 12 de Octubre — Madrid, Spain (enrolling)
- Hospital Regional Universitario de Malaga — Málaga, Spain (enrolling)
- Changhua Christian Hospital — Changhua, Taiwan (enrolling)
- Taichung General Veterans Hospital — Taichung, Taiwan (enrolling)
- National Taiwan University Hospital — Taipei, Taiwan (enrolling)
- Taipei Veterans General Hospital — Taipei, Taiwan (enrolling)
Full record on ClinicalTrials.gov
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