Focusing on the Menopausal Transition to Improve Mid-Life Women's Health
Recruiting now · Phase 2/Phase 3
Conditions studied: Menopause, Menopause Hot Flashes, Menopause Related Conditions, Cardiovascular
In brief
What if midlife women, who are inherently at an increased risk for future cardiometabolic disease due to transitioning into menopause, had access to a suite of evidence-based health interventions? Could these interventions reduce menopause-related inflammation, restore a healthier cardiometabolic profile, reverse epigenetic aging, and reduce bothersome menopausal symptoms? The ultimate goal of this work is to attenuate future disease and enhance women's quality of life, extend healthspan and increase productivity.
Key facts
- Study ID
- NCT06975111
- Run by
- University of Colorado, Denver
- People needed
- 200
- Starts
- 2026-03-01
- Expected to finish
- 2030-10-01
- Last updated by the study team
- 2026-07-21
Who can join
Age: 45 and older, up to 55. Sex: female. Healthy volunteers: accepted.
You may qualify if…
- aged 45-55
- In the late menopausal transition, defined as 60 days of amenorrhea but less than 365 days of amenorrhea18
- No current use of hormone therapy or hormonal contraception
- Presence of a uterus and at least one ovary in order to track menstrual patterns
- Have a smartphone and broadband access adequate to accept telehealth appointments
You may not qualify if…
- Lack of broadband access (activity and survey data will be collected electronically whenever possible and some visits will be via telehealth)
- Lack of regular menstrual periods in mid-reproductive life (ages 25-38) when not on hormones or not pregnant.
- Pregnancy or actively trying to get pregnant
- Inability to adhere to study protocol schedule
- Untreated alcoholism
- Un- Diagnosed abnormal uterine bleeding
- Personal or family history of medullary thyroid cancer or multiple endocrine neoplasia (MEN 2) for participants with a BMI> 30 kg/m2.
Where it is running
- University of Colorado-School of Medicine — Aurora, Colorado, United States (enrolling)
- University of North Carolina, School of Medicine — Chapel Hill, North Carolina, United States (enrolling)
- Virginia Commonwealth University — Richmond, Virginia, United States (enrolling)
Full record on ClinicalTrials.gov
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