A Clinical Trial of PF-08046037 Alone or With Sasanlimab in Patients With Advanced or Metastatic Malignancies
Stopped early · Phase 1
Conditions studied: Carcinoma, Non Small Cell Lung, Carcinoma, Pancreatic Ductal, Malignant Melanoma, Squamous Cell Carcinoma of the Head and Neck (SCCHN)
In brief
The purpose of this study is to learn about the safety and the effects of PF-08046037 alone or with sasanlimab for the treatment of certain advanced or metastatic malignancies. This study is seeking participants who: * have advanced or metastatic non-small cell lung cancer (NSCLC), head and neck squamous cell carcinoma (HNSCC), melanoma, or pancreatic ductal adenocarcinoma (PDAC); * are able to provide tumor tissue samples; * have measurable disease. All participants will receive while at the clinic PF-08046037 alone as an intravenous (IV) infusion (given directly into a vein) or with sasanlimab as a subcutaneous (SQ) injection (given under the skin) once every 3 weeks. Participants will continue to take the study drug(s) until their cancer is no longer responding or if the patient cannot safely take them. The study team will monitor how each participant is doing with the study treatment during regular visits at the study clinic.
Key facts
- Study ID
- NCT06974734
- Run by
- Pfizer
- People needed
- 8
- Starts
- 2025-05-06
- Expected to finish
- 2026-03-31
- Last updated by the study team
- 2026-04-23
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Presbyterian/ St. Lukes Medical Center — Denver, Colorado, United States
- Sarah Cannon Research Institute at HealthONE — Denver, Colorado, United States
- Smilow Cancer Hospital - Yale New Haven Health — New Haven, Connecticut, United States
- Yale - New Haven Hospital - Yale Cancer Center — New Haven, Connecticut, United States
- Smilow Cancer Hospital Phase 1 Unit — New Haven, Connecticut, United States
- Smilow Cancer Hospital - Trumbull — Trumbull, Connecticut, United States
- Community Health Network, Inc — Indianapolis, Indiana, United States
- Community Health Network, Inc. — Indianapolis, Indiana, United States
- Community Health Network, Inc. — Indianapolis, Indiana, United States
- Community Health Network, Inc. — Indianapolis, Indiana, United States
- START Midwest — Grand Rapids, Michigan, United States
- Sarah Cannon Research Institute - Pharmacy — Nashville, Tennessee, United States
- SCRI Oncology Partners — Nashville, Tennessee, United States
- Tristar Centennial Medical Center — Nashville, Tennessee, United States
- Pan American Center for Oncology Trials, LLC — Rio Piedras, Puerto Rico
Full record on ClinicalTrials.gov
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