Non-Narcotic Pain Control After ACL Reconstruction

Running, not enrolling · Phase 3

Conditions studied: ACL - Anterior Cruciate Ligament Rupture, ACL Injuries

In brief

This is a double-blind randomized controlled trial of standard of care therapy, either oral ketorolac (experimental group) or oral oxycodone (control group) to demonstrate efficacy in reducing the percentage of narcotic doses taken and documenting the number of patients with no exposure to any narcotics (take zero oxycodone) after undergoing primary knee ACL reconstruction outpatient surgery.

Key facts

Study ID

NCT06973785

Run by

The Cleveland Clinic

People needed

30

Starts

2025-07-15

Expected to finish

2027-06-15

Last updated by the study team

2026-06-15

Who can join

Age: 15 and older, up to 55. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Provision of signed and dated informed consent form
• Stated willingness to comply with all study procedures and availability for the duration of the study
• Male or female, aged 15-55 years
• Primary Autograft ACL surgery
• Ability to take oral medication and willingness to patriciate in a virtual 1 and 2 week follow-up pill counts

You may not qualify if…

• Provision of signed and dated informed consent form
• Stated willingness to comply with all study procedures and availability for t the duration of the study
• Male or female, aged 15-55 years
• Primary Autograft ACL surgery
• Ability to take oral medication and willingness to patriciate in a virtual 1 and 2 week follow-up pill counts

Where it is running

• Cleveland Clinic Coral Springs — Coral Springs, Florida, United States
• Cleveland clinic sports medicine — Garfield, Ohio, United States
• Cleveland Clinic — Strongsville, Ohio, United States

Full record on ClinicalTrials.gov

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