Bacillus Cereus Invasive Infections in Preterm Neonates Hospitalized in French Hospitals

Recruiting now

Conditions studied: Sepsis, Infections

In brief

Background. Bacillus cereus group (Bc) comprises twenty-six closely related species of spore-forming environmental bacteria. Recently, increased sepsis and septic shock caused by Bc were reported in preterm neonates (PN), and the mortality rate can reach up to 30%. Using Whole Genome Sequencing (WGS) increasingly used to characterize Bc strains, The team aimed to determine an accurate identification to the species level of the strains involved in Bc invasive infections in preterm neonates in France and study their virulome profile.Methods. The team performed WGS for 40 neonate clinical strains responsible for invasive infections in PN. A screening of virulence genes was performed to characterize strains associated with poor prognosis. Clinical data were collected and all clinical and genomic findings were analyzed for risk factors for death. "

Key facts

Study ID

NCT06973174

Run by

Centre Hospitalier Universitaire de Nice

People needed

40

Starts

2010-01-01

Expected to finish

2026-12-30

Last updated by the study team

2026-01-28

Who can join

Age: any, up to 0. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Premature newborn (i.e born before 37 last menstrual periods) with invasive infection caused by B. cereus (strains isolated from blood culture and cerebrsopinal fluid)

You may not qualify if…

• None

Where it is running

• CHU NICE — Nice, Alpes Maritimes, France (enrolling)
• CHU lille — Lille, France (enrolling)
• AP-HM Marseille — Marseille, France (enrolling)
• CHU Nantes — Nantes, France (enrolling)
• CHU Nîmes — Nîmes, France (enrolling)
• AP-HP Hôpital Robert Debré — Paris, France (enrolling)
• Hôpital Antoine Béclère, AP-HP — Paris, France (enrolling)
• Hôpital Cochin — Paris, France (enrolling)
• CHU de Poitiers — Poitiers, France (enrolling)
• CHU Rennes — Rennes, France (enrolling)
• CHRU de Strasbourg — Strasbourg, France (enrolling)
• CHU Toulouse — Toulouse, France (enrolling)
• CHU de Tours — Tours, France (enrolling)

Full record on ClinicalTrials.gov

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