Bone and Body Composition Adaptations to Physical Training

Completed · Not applicable

Conditions studied: Exercise, Healthy

In brief

The goal of this clinical trial is to evaluate how different exercise programs alter bone density, structure, and strength in adults. It will also collect data on hormones, factors released from skeletal muscle, and body composition. The main questions it aims to answer are: * Do exercise programs that are frequent with high-impact loading will cause greater improvements in bone health? * What changes in hormones, factors released from skeletal muscle, and body composition contribute to bone adaptations? Researchers will compare different exercise groups to see if the type of exercise influences bone adaptation compared to a recreationally active control group. Participants are asked to: * complete questionnaires, 5 blood draws across the study (3 at rest, 2 after strenuous exercise), dual energy x-ray absorptiometry (DXA) scans (to assess bone mineral density and body composition), high resolution tibial scans to assess bone structure and geometry, and physical performance testing. * attend up to 7 testing visits. * (for those randomized to the exercise training intervention) participate in exercise training sessions for 6 months.

Key facts

Study ID

NCT06972862

Run by

University of Pittsburgh

People needed

206

Starts

2022-08-29

Expected to finish

2025-04-27

Last updated by the study team

2025-05-15

Who can join

Age: 18 and older, up to 40. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Age 18-40 years
• Body mass index (BMI) 18-28 kg/m2
• Weight stable (±10 lbs) in past 2 months
• Takes part in moderate physical activity for at least 150 minutes/week
• Currently free of upper or lower body /extremity injury or impairment
• Comfortable with multiple blood draws
• Able to commit to the 6-month study duration
• Agrees to adhere to study requirements.

You may not qualify if…

• Current smoker
• Current clinical diagnosis of an eating disorder
• Chronic use of non-steroidal anti-inflammatory drugs (NSAIDs). NSAID use is defined as chronic if these medications are taken more than three times a week for more than 12 consecutive weeks.
• Use of medication incompatible with measurement of reproductive, metabolic, or bone-related hormones (including thyroid medications, glucocorticoids) or which includes anti-coagulants and may interfere with any of the study outcomes
• Current oligo/amenorrhea in women, not explained by contraceptive use
• Any metabolic or endocrine disease that affects bone; Individuals taking hormonal therapy for transgender care
• Currently training for a competitive sporting event or planning to start
• Weight has fluctuated by 10 pounds or more in the past 2 months based on subject self-report
• Has been diagnosed with a medical condition, physical or psychological, that currently prevents exercise participation
• Has suffered a musculoskeletal injury removing them from physical activity for more than a month, within the past two years
• Currently pregnant or becomes pregnant during the study (as assessed by urine pregnancy tests at 0, 3 \& 6 months)
• Current asthma diagnosis, defined as experienced symptoms or been prescribed any form of treatment within the last 4 years, or those who have required more than one course of oral steroids or more than one nebulization since the age of 5 (JSP 950), will require a note/permission from treating physician to participate in study. Those who have had a single admission to intensive care or high dependency, or multiple admissions to hospital will be excluded from participating (JSP 950)
• History of heart condition OR high blood pressure
• Feeling of pain in the chest during rest, activities of daily living, or physical activity
• Have lost balance or consciousness due to dizziness in the last 12 months (with the exception of dizziness due to hyperventilation)
• Treating physician requires subject participates in medically supervised physical activity only
• History of drug addiction or habitual recreational drug use (2 or more times per month in each of the previous six months)
• Low bone mineral density indicated as a Z-score <-1.0 measured by dual-energy x-ray absorptiometry (DXA)

Where it is running

• University of Kansas, Jayhawk Performance Laboratory — Lawrence, Kansas, United States
• Neuromuscular Research Laboratory — Pittsburgh, Pennsylvania, United States

Full record on ClinicalTrials.gov

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