A Study of Orforglipron (LY3502970) in Participants With Obesity or Overweight and Type 2 Diabetes

Running, not enrolling · Phase 3 · Has a placebo group

Conditions studied: Obesity, Overweight, Type 2 Diabetes

In brief

The main purpose of this study is to see how orforglipron, compared with placebo, helps improve glycemic control in participants with obesity or with overweight and type 2 diabetes. This trial is part of the master protocol study J2A-MC-GZPO (NCT06993792). Participation in the study will last about 18 months.

Key facts

Study ID

NCT06972472

Run by

Eli Lilly and Company

People needed

600

Starts

2025-05-19

Expected to finish

2027-08-01

Last updated by the study team

2026-04-20

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Have body mass index (BMI) ≥25 kilograms per square meter (kg/m2) at screening
• Have type 2 diabetes
• Have hemoglobin A1c (HbA1c) ≥7% and ≤10% at screening
• Have a history of at least one unsuccessful dietary effort to lose body weight

You may not qualify if…

• Have type 1 diabetes
• Have an unstable body weight within 90 days prior to screening
• Have New York Heart Association functional classification IV congestive heart failure or an acute cardiovascular condition within 90 days prior to screening
• Have acute or chronic hepatitis or pancreatitis
• Are taking other medications or alternative remedies to manage weight loss

Where it is running

• Novak Clinical Research - Tucson - North La Cholla Boulevard — Tucson, Arizona, United States
• Norcal Endocrinology & Internal Medicine — San Ramon, California, United States
• Southern California Clinical Research — Santa Ana, California, United States
• Care Access - Thousand Oaks — Thousand Oaks, California, United States
• Accel Research Sites - DeLand Clinical Research Unit — DeLand, Florida, United States
• Innovation Medical Research Center - Fort Lauderdale — Fort Lauderdale, Florida, United States
• Indago Research & Health Center, Inc — Hialeah, Florida, United States
• Encore Medical Research — Hollywood, Florida, United States
• West Orange Endocrinology P.A. — Ocoee, Florida, United States
• Care Access - Tampa — Tampa, Florida, United States
• Conquest Research — Winter Park, Florida, United States
• Accel Research Sites - NeuroStudies Clinical Research Unit — Decatur, Georgia, United States
• Care Access - Decatur — Decatur, Georgia, United States
• Javara - Privia Medical Group Georgia - Savannah — Savannah, Georgia, United States
• North Georgia Clinical Research — Woodstock, Georgia, United States
• Solaris Clinical Research — Meridian, Idaho, United States
• Care Access - New Iberia — New Iberia, Louisiana, United States
• Endocrine and Metabolic Consultants — Rockville, Maryland, United States
• Javara - Privia Medical Group - Silver Spring — Silver Spring, Maryland, United States
• Great Lakes Research Group, Inc. — Bay City, Michigan, United States
• Boeson Research MSO — Missoula, Montana, United States
• Javara - Nevada Health Centers - Carson City — Carson City, Nevada, United States
• The Machuca Foundation — Las Vegas, Nevada, United States
• University of North Carolina Medical Center — Chapel Hill, North Carolina, United States
• Clinical Research Institute of Arizona (CRI) - Sun City West — Sun City West, Arizona, United States

Full record on ClinicalTrials.gov

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