Tolerance Through Mixed Chimerism (Sip-Tego)
Recruiting now · Early Phase 1
Conditions studied: Kidney Failure, Transplant Recipient (Kidney), Transplant Tolerance, Immunosuppresion, Immunosuppression After Kidney Transplantation
In brief
This is an open-label, single-institution study to assess the safety and the efficacy of the Sip-Tego regimen for the induction of donor-specific immunologic unresponsiveness to a renal allograft. The investigators propose to treat 6 adult subjects in end-stage renal disease (ESRD) who do not demonstrate evidence of prior sensitization.
Key facts
- Study ID
- NCT06972069
- Run by
- Tatsuo Kawai, MD, PhD
- People needed
- 12
- Starts
- 2025-05-31
- Expected to finish
- 2030-12-31
- Last updated by the study team
- 2026-07-22
Who can join
Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Massachusetts General Hospital — Boston, Massachusetts, United States (enrolling)
Full record on ClinicalTrials.gov
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