Direct Carotid Sinus Nerve Stimulation in Anesthetized Human Subjects

Completed · Not applicable

Conditions studied: HTN-Hypertension, Blood Pressure Management

In brief

Uncontrolled hypertension (HTN) is growing in incidence globally creating a critical need for alternative therapeutic strategies. Directly stimulating the carotid sinus nerve (CSN) is known to potentially reduce blood pressure (BP) but its clinical efficacy has not been consistently demonstrated with existing electrode technologies in humans. We investigated the effect of acute direct CSN stimulation on BP and HR in anesthetized humans using an application-specific multi-contact electrode.

Key facts

Study ID

NCT06969846

Run by

Louis Stokes VA Medical Center

People needed

18

Starts

2020-04-03

Expected to finish

2024-08-12

Last updated by the study team

2025-05-14

Who can join

Age: any. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• . Eligible patients were those scheduled to undergo elective surgical procedure that therapeutically indicated exposure of the carotid bifurcation and vascular sheath (e.g. carotid endarterectomy, neck dissection, or carotid tumor Resection) regardless of a HTN diagnosis.

You may not qualify if…

• history of stroke
• prior ipsilateral neck surgery or radiation treatment
• Cardiovascular disease that precluded enrollment were diagnoses which independently increased surgical and anesthetic risk (American Society for Anesthesia Classification System).

Where it is running

• VA Northeast Ohio Healthcare System — Cleveland, Ohio, United States

Full record on ClinicalTrials.gov

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