Mechanical Dyssynchrony and Microvascular Dysfunction by SPECT

Recruiting now

Conditions studied: Myocardial Blood Flow Reserve, Mechanical Dyssynchrony, Coronary Arterial Disease (CAD)

In brief

The project is aimed at studying the feasibility of mechanical dyssynchrony of the left ventricle of the heart, determined by SPECT (gated MPI), as well as its stress-induced dynamics, in the evaluation of patients with coronary microvascular dysfunction in chronic coronary heart diseasу.

Key facts

Study ID

NCT06969547

Run by

Tomsk National Research Medical Center of the Russian Academy of Sciences

People needed

75

Starts

2023-10-01

Expected to finish

2026-05-15

Last updated by the study team

2025-09-24

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Ischemia with no obstructive coronary arteries (INOCA)
• Obstructive coronary artery disease (CAD)
• Patients without evidence of coronary heart disease

You may not qualify if…

• Left ventricular ejection fraction <55% according to echocardiography;
• History of myocardial infarction/revascularization;
• hypertension: systolic blood pressure >180 mm Hg. Art., diastolic BP>110 mm Hg. Art.;
• systolic arterial hypotension <80 mm Hg. Art.;
• atrial fibrillation;
• AV blockade of the III degree; sick sinus syndrome;
• massive pulmonary embolism (PE) with a high degree of pulmonary hypertension;
• the presence of significant valvular pathology (mitral insufficiency ≥ 3 degrees, aortic insufficiency ≥ 3 degrees, tricuspid regurgitation ≥ 3 degrees).
• severe course of bronchial asthma, chronic obstructive pulmonary disease;
• decompensated type 2 diabetes,
• severe liver or kidney failure (glomerular filtration rate <50 ml/min/1.73 m3 (CKD-EPI),
• morbid obesity (body mass index >45);
• history of myocarditis
• indications of poor drug tolerance;
• oncological diseases;
• chronic alcoholism, mental disorders;
• other severe comorbidity,
• refusal to participate in the study.

Where it is running

• Tomsk NRMC Cardiology Research Institute — Tomsk, Russia (enrolling)

Full record on ClinicalTrials.gov

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