Mitigating Delirium With Fluvoxamine Treatment for Non-Cardiac Surgery

Recruiting now · Phase 3 · Has a placebo group

Conditions studied: Delirium, Surgery-Complications

In brief

The investigation will establish biological plausibility and infrastructure required for a multisite clinical trial evaluating the re-purposing of fluvoxamine to mitigate postoperative delirium risk in geriatric patients undergoing non-cardiac non-intracranial surgery.

Key facts

Study ID

NCT06969287

Run by

Washington University School of Medicine

People needed

46

Starts

2026-04-06

Expected to finish

2028-04-01

Last updated by the study team

2026-04-29

Who can join

Age: 60 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• English-speaking
• elective non-cardiac or non-intracranial surgery requiring at least a 2-day hospital length of stay

You may not qualify if…

• Received investigational drug within the last 7 weeks
• lack of capacity to provide informed consent
• prior known intolerance or allergy to SSRIs or fluvoxamine
• planned postoperative ventilation
• drug or alcohol dependence
• preoperative use of non-NSAID medications with drug-drug interactions of Class X (Avoid Combination) or D (Consider Therapy Modification)
• risk of serotonin syndrome (St John's Wort, SSRIs, or TCA)

Where it is running

• Washington University School of Medicine/Barnes-Jewish Hospital — St Louis, Missouri, United States (enrolling)

Full record on ClinicalTrials.gov

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