Project COMET: Massed Prolonged Exposure for PTSD and SUD
Recruiting now · Not applicable
Conditions studied: Posttraumatic Stress Disorder (PTSD), Substance Use Disorders (SUD), Comorbidity, Trauma and Stressor Related Disorders
In brief
The goal of this clinical trial is to learn if Massed Prolonged Exposure Therapy (M-PE) can improve PTSD symptoms and reduce substance use in adults receiving intensive outpatient (IOP) treatment for substance use disorder (SUD). The main questions it aims to answer are: * Does M-PE reduce PTSD symptoms more effectively than trauma treatment as usual (TAU)? * Does M-PE reduce the number of days participants use substances? * How do patient-centered outcomes (such as depression, suicidal thoughts, and quality of life) differ between M-PE and trauma TAU? * Researchers will compare M-PE to treatment as usual to see if M-PE leads to better mental health and substance use outcomes and lower dropout rates. Participants will: * Attend multiple therapy sessions per week (M-PE) or receive usual care * Complete assessments at baseline, during treatment, end-of-treatment, 1-month, 3-month, and 6-month follow-up * Share feedback through surveys and interviews about their experience in the program
Key facts
- Study ID
- NCT06968832
- Run by
- Rutgers, The State University of New Jersey
- People needed
- 168
- Starts
- 2025-09-02
- Expected to finish
- 2029-06-30
- Last updated by the study team
- 2025-10-27
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age 18+
- Enrolled in SUD treatment at Gateway Community Services
- Meet DSM-5 criteria for a SUD (Tobacco Use Disorder alone not sufficient for inclusion)
- Meet DSM-5 criteria for PTSD
- Able to give informed consent
You may not qualify if…
- severe cognitive impairment
- current suicidal or homicidal intent requiring immediate treatment
- current unstable psychotic or manic symptoms not attributable to SUD
Where it is running
- Gateway Community Services — Jacksonville, Florida, United States (enrolling)
Full record on ClinicalTrials.gov
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