Spatiotemporal Thalamocortical Alterations Underlie Experimental and Chronic Pain

Recruiting now · Not applicable · Has a placebo group

Conditions studied: Pain

In brief

The purpose of this study is to assess thalamocortical (TC) connectivity during tonic pressure pain, to evaluate alpha activity during tonic pressure pain and to determine pressure pain ratings by using Electroencephalography (EEG), Functional Magnetic Resonance Imaging (fMRI), Transcranial Alternating Current Stimulation (tACS), sham and Transcranial random noise stimulation (tRNS)

Key facts

Study ID: NCT06968689
Run by: The University of Texas Health Science Center, Houston
People needed: 60
Starts: 2025-06-01
Expected to finish: 2028-02-29
Last updated by the study team: 2026-03-02

Who can join

Age: 18 and older, up to 60. Sex: any. Healthy volunteers: accepted.

You may qualify if…

Meet the MRI / EEG screening criteria
Fluent in English

You may not qualify if…

Current or history of major medical, neurological, or psychiatric illness based on self-report
History of cardiac, respiratory, or nervous system disease that, in the investigator's judgment, precludes participation in the study because of a heightened potential for adverse outcome (for example: asthma or claustrophobia)
History of head trauma
Pregnant or lactating
Presence of any contraindications to MRI scanning (for example: cardiac pacemaker, metal implants, claustrophobia, pregnancy, cannot lie still in fMRI scanner)
Conditions making study participation difficult (e.g., paralysis, psychoses, or other severe psychological problems as per the judgment of a study investigator during Session 1)
Active substance abuse disorders (based on subject self-report)

Where it is running

The University of Texas Health Science Center at Houston — Houston, Texas, United States (enrolling)

Full record on ClinicalTrials.gov

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