Transcranial Magnetic Stimulation + Language Therapy to Treat Subacute Aphasia
Recruiting now · Phase 2
Conditions studied: Stroke, Aphasia, Aphasia Following Cerebral Infarction
In brief
The goal of this clinical trial is to determine if Transcranial Magnetic Stimulation (TMS) combined with modified Constraint Induced Language Therapy (mCILT) is an effective treatment for aphasia when delivered in the subacute stage after stroke. The main questions this study aims to answer are: 1. Can TMS combined with mCILT improve overall speech? 2. Can we identify specific behavioral and biological characteristics that would benefit most from the TMS and mCILT treatment? Researchers will compare real TMS to sham (fake) TMS to see whether TMS can treat subacute aphasia. Importantly, this trial will use electric field guided TMS to identify optimal and individualized stimulation intensity and site targeting. Participants will: * Complete a screening and medical intake to determine eligibility * Undergo MRI scans * Participate in 10 consecutive sessions (Monday-Friday) of TMS and mCILT treatment * Complete follow-up assessments immediately and 4 months after treatment
Key facts
- Study ID
- NCT06968663
- Run by
- University of Pennsylvania
- People needed
- 63
- Starts
- 2024-08-01
- Expected to finish
- 2029-07-31
- Last updated by the study team
- 2026-06-18
Who can join
Age: 18 and older, up to 85. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Left hemisphere stroke resulting in aphasia
- The stroke must have occurred between 2 and 6 weeks prior to enrollment
- Must be able to understand the nature of the study, and give informed consent
- English proficiency
- Right-handed
You may not qualify if…
- History of serious and/or ongoing issues with substance abuse
- Previous head trauma with loss of consciousness for more than 5 minutes
- History of major psychiatric illness
- Dementia, or other neurological conditions
- Epilepsy, or seizure after the stroke event
- Pacemaker
- Diagnosis of tinnitus
- Pregnancy
Where it is running
- University of Pennsylvania — Philadelphia, Pennsylvania, United States (enrolling)
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.