Hexadecanal as an Addon to Cognitive Processing Therapy for PTSD

Recruiting now · Not applicable

Conditions studied: Post Traumatic Stress Disorder (PTSD)

In brief

This RCT investigates whether Cognitive Processing Therapy, a first line treatment for PTSD, can be enhanced by the use of the odor molecule Hexadecenal (HEX). HEX is secreted from body odor and has been shown to promotes psychological well-being and positive social interaction. For the active group Hex will be diffused in the treatment room during all treatment sessions. For the control group a vehicle placebo molecule will be diffused. Both therapists and patients will be blind to study condition.

Key facts

Study ID

NCT06968312

Run by

Tel Aviv University

People needed

40

Starts

2025-05-05

Expected to finish

2026-12-30

Last updated by the study team

2025-05-16

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosis of PTSD according to DSM-5
• Age 18 years and over
• Eligible for CPT treatment at the National Center for Traumatic Stress and Resilience

You may not qualify if…

• Bipolar disorder, psychosis, neurological disorders
• Drug Addiction
• Parallel psychotherapy
• Congenital or acquired anosmia.

Where it is running

• Tel Aviv University — Tel Aviv, Israel (enrolling)

Full record on ClinicalTrials.gov

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