Reconstruction With a Lawrence-Hunt Jejunal Pouch After Total Gastrectomy

Recruiting now · Not applicable

Conditions studied: Total Gastrectomy, Gastric Cancer

In brief

The aim of the study is to establish the efficacy of jejunal pouch reconstruction in reducing dumping syndrome in patients undergoing total gastrectomy, ultimately enhancing postoperative quality of life and nutritional status.

Key facts

Study ID

NCT06967571

Run by

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

People needed

26

Starts

2026-01-01

Expected to finish

2028-04-01

Last updated by the study team

2026-07-23

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adults aged 18-75 years.
• Histologically confirmed gastric tumor (including adenocarcinoma, gastrointestinal stromal tumor - GIST- or neuroendocrine tumor) or patients with CDH1 mutation, scheduled for TG with a maximal esophageal resection of < 6 cm.
• Informed consent capability.

You may not qualify if…

• Prior abdominal surgeries affecting the jejunum.
• Severe comorbidities or non-appropriate organ function: uncontrolled diabetes with HbA1C > 7.5, significant heart disease: New York Heart Association (NYHA) functional classification Class III or IV, chronic obstructive pulmonary disease (COPD) requiring oxygen supplementation or continuous positive airway pressure (CPAP), chronic corticosteroid therapy (daily for more than 6 months), neutrophil count < 2000/mm3, hemoglobin < 8.0 g/dL, platelet count < 100,000/mm3, serum total bilirubin > 1.5 mg/dL, serum aspartate aminotransferase (AST) >100 IU/L, serum alanine aminotransferase (ALT) >100 IU/L, and creatinine clearance (CCr) ≥ 50 mL/min), ECOG performance status > 1.
• Pregnancy or breastfeeding.

Where it is running

• Fondazione Policlinico Universitario A. Gemelli IRCCS — Roma, Italy (enrolling)

Full record on ClinicalTrials.gov

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