Comparison of Alpha Blockers (Terazosin and Tamsulosin) in Reducing Ureteral Stent Related Symptoms
Recruiting now · Phase 3
Conditions studied: Stent Related Symptoms
In brief
The goal of this clinical trial is to compare how well Terazosin, Tamsulosin and standard care (no alpha-blocker) reduce urinary symptoms after ureteral stent placement. This trial also learn about the safety of these two study medications. Main objective: • To compare how well Terazosin, Tamsulosin and standard of care reduce post-stenting urinary symptoms. Secondary objectives: * To assess differences in Body pain, General health, Work performance, Sexual matters, and Additional problems using a questionnaire (USSQ). * To assess differences in side effects. After stent placement, subjects will be randomly assigned to one of three groups: 1. Terazosin (alpha-blocker) for 14 days 2. Tamsulosin (alpha-blocker) for 14 days 3. Standard of care (no alpha-blocker). All subjects will be discharged with standard pain-killers and a diary to track usage. Subjects in Terazosin and Tamsulosin groups will receive respective study medications to complete 14 days course of treatment. Follow-Up: * Day 7: A phone call will check medication use and any side effects. * Day 15: Clinic visit for stent removal (standard practice). Subjects will complete the USSQ questionnaire, and medication compliance will be reviewed. End of study: Final phone call to check for any additional side effects.
Key facts
- Study ID
- NCT06966804
- Run by
- Penang Hospital, Malaysia
- People needed
- 150
- Starts
- 2025-06-01
- Expected to finish
- 2027-07-31
- Last updated by the study team
- 2026-07-24
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Malaysian age 18 years old and above.
- Able to provide written informed consent to participate in the trial.
- Willing to comply with study procedures.
- Unilateral intracorporeal lithotripsy procedure with ureteral stent placement for uncomplicated ureteric or renal calculi
You may not qualify if…
- Known comorbidity that increase the risk of complication
- Prostate pathology: Benign prostate hyperplasia, prostatitis, prostatic carcinoma
- Bladder pathology: Bladder tumor, stone, overactive bladder
- Ureteral abnormality/ trauma, urethral stricture
- Concomitant urinary tract infection
- Orthostatic hypotension
- Solitary kidney
- Previous pelvic/ gynaecological surgery
- Patient is concomitantly receiving treatment from a pain clinic for chronic pain management.
- Pregnancy (for women of childbearing potential)
- Known history of allergic reactions to tamsulosin or terazosin
- Patient is concomitantly taking warfarin or H2 receptor blockers
- Patients with clinical condition(s) judged by the researcher/ clinician to be unsuitable for participation in the study
Where it is running
- Sultanah Bahiyah Hospital, Alor Setar — Alor Star, Kedah, Malaysia (enrolling)
- Hospital Pulau Pinang — George Town, Pulau Pinang, Malaysia (enrolling)
Full record on ClinicalTrials.gov
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