Comparison of Continuous Positive Airway Pressure (CPAP) and Non-Invasive Positive Pressure Ventilation (NIPPV) in Preterm Newborns With Respiratory Distress Syndrome.

Recruiting now · Not applicable

Conditions studied: Respiratory Distress Syndrome (RDS)

In brief

Primary objective: to evaluate safety and efficacy of two different non-invasive respiratory support modalities in preterm neonatal patients with respiratory distress syndrome. Secondary objective is to compare different respiratory support mode performance in different gestational age groups. Primary endpoint is treatment failure. With this study, the following hypotheses will be tested: Hypothesis 1: NIPPV has a lower failure rate compared to CPAP mode. Hypothesis 2: NIPPV complication rate is non-superior compared to CPAP.

Key facts

Study ID

NCT06966752

Run by

Vilnius University

People needed

150

Starts

2025-03-25

Expected to finish

2027-05-01

Last updated by the study team

2025-05-13

Who can join

Age: any, up to 1. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• gestational age (GA) between 22+0 and 34+6 weeks (estimated on the postmenstrual date and early gestation ultrasonographic findings).
• Need of respiratory support (deemed by a clinician).

You may not qualify if…

• Major congenital anomalies
• Cardiovascular instability
• Consent refused or not provided

Where it is running

• Vilnius University Santaros Klinikos — Vilnius, Vilnius County, Lithuania (enrolling)

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.