Investigation of the Interplay Between Local Oral Inflammation, Microbiota and Systemic Immune Responses.

Starting soon · Phase 4

Conditions studied: Gingival Inflammation

In brief

This is a clinical research study designed to measure changes in inflammation and the oral microbiome during a phase of good oral hygiene and the absence of oral hygiene. The goal of the study is to investigate the interplay between local oral inflammation, microbiota and systemic immune responses.

Key facts

Study ID

NCT06966492

Run by

Colgate Palmolive

People needed

20

Starts

2026-06-01

Expected to finish

2027-06-01

Last updated by the study team

2026-05-26

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Males and females, between 18-65 years of age;
• Availability for the duration of the study;
• ASA 1 Good general health (absence of any self-reported systemic disease or condition that, in the opinion of the Principal Investigator, might constitute a risk to the subject while participating in the study. Examples include heart problems, valve/hip replacements, etc);
• Willingness to provide information related to their medical history;
• Minimum of 20 uncrowned permanent natural teeth (excluding third molars and crowns);
• Informed Consent Form signed.

You may not qualify if…

• Subjects with more that 2 sites with pocket depth of > 4 mm and those presenting purulent exudate, tooth mobility, and/or extensive loss of periodontal attachment or alveolar bone;
• Oral pathology or a history of allergy to testing products;
• Subject using anticonvulsants, antihistamines, antidepressants, sedatives, tranquilizers, anti-inflammatory medication or daily analgesics within one month prior to the start of the study or scheduled to start such intake during the course of the study; to be defined by the dental examiner;
• Subject participating in any other clinical study;
• Subject pregnant or breastfeeding;
• Subject allergic to oral care products and personal care consumer products
• Extended use of antibiotics or therapeutic mouthwash (eg: Chlorhexidine) any time during the three months prior to entry into the study;
• Ongoing use of medications known to affect the gingival tissues (i.e. calcium channel blockers, phenytoin, cyclosporine)
• Current smokers (or users of tobacco and vaping products) and subjects with a history of alcohol or drug abuse;
• An existing medical condition which prohibits eating or drinking for periods up to 4 hours.
• Individuals with orthodontic bands or removable partial dentures.
• Dental prophylaxis in the previous 3 months prior to the baseline examination

Where it is running

• UT Health School of Dentistry — Houston, Texas, United States

Full record on ClinicalTrials.gov

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