To Determine Whether it is Feasible to Treat Patients Requiring Urgent Radiotherapy Diagnosed With Metastatic Cord Compression (MSCC) on the Magnetic Resonance Linear Accelerator (MRL) in a Single Appointment and Compare it to the Standard of Care Radiotherapy Pathway

Recruiting now · Not applicable

Conditions studied: Metastatic Spinal Cord Compression

In brief

The goal of this clinical trial is to understand whether the Magnetic Resonance Linear Accelerator (MRL) could expedite Radiotherapy treatment for Metastatic Cord Compression (MSCC) by removing the need for a planning CT (pCT) scan prior to treatment. Radiotherapy will be delivered in one appointment on the MRL and compared to the standard of care of two appointments: a CT scan and a Radiotherapy appointment. The main questions it aims to answer are: * Can the MRL deliver successful treatment of MSCC in a single 1-hour appointment? * Can the MRL treat participants within 24 hours from the doctor's decision to treat? * Did it take less time from consent to completion of treatment when patients were treated on the MRL? * Do the questionnaire scores reflect satisfaction with treatment on the MRL? Researchers will compare treatment on the MRL in one appointment to a group receiving standard of care radiotherapy in two appointments. Participants in both groups will receive the same prescription of 8Gray (Gy) in one treatment (fraction) delivered with one posterior-anterior beam as per our department policies and national standards. Participants will be asked to complete an optional questionnaire prior to treatment to monitor the diversity of the study population. This questionnaire is anonymised, no personal data that could identify a participant is collected on this questionnaire. After treatment participants will be asked to complete an experience questionnaire, to assess treatment experience. Once the questionnaire is complete active participation in the trial is no longer needed, researchers will monitor participants notes for up to 12 months after treatment to record participant well being and function.

Key facts

Study ID

NCT06965101

Run by

The Christie NHS Foundation Trust

People needed

72

Starts

2025-11-04

Expected to finish

2028-11-04

Last updated by the study team

2025-12-02

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Confirmed Diagnosis of MSCC
• Referred for an 8Gy, Single Fraction of Radiotherapy
• 18 years or older.
• Able to give informed consent in writing or verbally.
• Willing to complete patient experience questionnaire
• Willing to have the research team review their case notes for up to 1 year following

You may not qualify if…

• Participant does not have capacity and cannot give informed consent.
• Any evidence of significant clinical disorder or laboratory finding which, in the opinion of the investigator, make it undesirable for the patient to participate in the study.
• Participant is unwilling to allow researchers to access their clinical notes and diagnostic scans.
• Participant is unwilling to complete an experience questionnaire
• The participant cannot speak or understand English.
• Exclusion Criteria MRL arm:
• Any contraindications to MRI identified after MRI safety screening
• Unable to tolerate MRI scanning
• Uncontrolled pain/ poor pain control.
• MSCC in the cervical spine.
• More than one vertebral level of compression

Where it is running

• The Christie NHS Foundation Trust — Manchester, United Kingdom (enrolling)

Full record on ClinicalTrials.gov

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