Microplastics and Nanoplastics (MNPs) in Patients With ST-elevation Myocardial Infarction (STEMI)
Recruiting now
Conditions studied: ST-elevation Myocardial Infarction (STEMI), Microplastics, Nanoplastics, Pollution Exposure
In brief
Air pollution and microplastics pose major public health threats. Emerging data have shown that micro- and nanoplastics (MNPs) are ubiquitous environmental pollutants accumulating in human tissues, triggering inflammation and prothrombotic state. This study will investigate the presence and burden of MNPs within coronary thrombi/thromboaspirate of patients presenting with ST segment elevation acute myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention and their association with cardiac damage, plaque vulnerability, microvascular obstruction, and cardiovascular events. Plaque vulnerability will be explored by optical coherence tomography, while microvascular obstruction will be assessed by bolus thermodilution and cardiac magnetic resonance. Participants will be followed up for 1-year to evaluate whether the presence and the burden of MNPs will be associated with a higher incidence of the cardiovascular events.
Key facts
- Study ID
- NCT06965023
- Run by
- Azienda Ospedaliera "Sant'Andrea"
- People needed
- 130
- Starts
- 2025-04-22
- Expected to finish
- 2027-12-31
- Last updated by the study team
- 2025-05-11
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- All the following inclusion criteria should be fulfilled:
- Age > 18 years old;
- STEMI undergoing urgent invasive coronary angiography;
- Acute thrombotic coronary occlusion/sub-occlusion (TIMI 0/1);
- Clinical indication to thromboaspiration;
- Able to give informed consent.
You may not qualify if…
- Contraindications to percutaneous coronary intervention;
- Hemodynamic instability or cardiogenic shock;
- End-stage chronic kidney disease;
- Life expectancy < 1 year due to non-cardiac pathology.
Where it is running
- Sant'Andrea University Hospital — Roma, Rome, Italy (enrolling)
- Azienda Ospedaliera Integrata Verona, Italy — Verona, Italy (enrolling)
- Division of Cardiology, A.O.R.N. "Sant'Anna e San Sebastiano", Caserta, Italy. — Caserta, Italy
- Cardiovascular Department, A.O.U. Policlinico "G. Rodolico - San Marco", University of Catania, Catania, Italy. — Catania, Italy
- Azienda Ospedaliero Universitaria di Ferrara, Cona, Italy — Ferrara, Italy
- Cardiovascular Division, Morgagni-Pierantoni University Hospital, Forlì, Italy. — Forlì, Italy
- Interventional Cardiology Unit, De Gasperis Cardio Center, Niguarda Hospital, Milan, Italy. — Milan, Italy
- Department of Advanced Medical and Surgical Sciences, University of Campania-Luigi Vanvitelli, Naples, Italy. — Naples, Italy
- Division of Cardiology, Cardiovascular and Thoracic Department, Città della Salute e della Scienza, Turin, Italy. — Turin, Italy
- Department of Environmental Biological and Pharmaceutical Sciences and Technologies, University of Campania "Luigi Vanvitelli — Caserta, Italy
Full record on ClinicalTrials.gov
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