A Study Evaluating the Efficacy and Safety of ALG-000184 Compared With Tenofovir Disoproxil Fumarate in Untreated HBeAg-Positive and HBeAg- Negative Adult Subjects With Chronic Hepatitis B (B-SUPREME)

Recruiting now · Phase 2

Conditions studied: Chronic Hepatitis B Infection

In brief

This is a Phase 2 study to evaluate efficacy and safety of 48 weeks of oral once daily monotherapy with ALG-000184 versus tenofovir disproxil fumarate (TDF) for chronic HBV infection.

Key facts

Study ID

NCT06963710

Run by

Aligos Therapeutics

People needed

200

Starts

2025-07-15

Expected to finish

2028-08-01

Last updated by the study team

2026-05-01

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

Where it is running

• Aligos Investigational Site — Coronado, California, United States (enrolling)
• Aligos Investigational Site — Garden Grove, California, United States (enrolling)
• Aligos Investigational Site — Los Angeles, California, United States (enrolling)
• Aligos Investigational Site — Palo Alto, California, United States (enrolling)
• Aligos Investigational Site — Pasadena, California, United States (enrolling)
• Aligos Investigational Site — Rialto, California, United States (enrolling)
• Aligos Investigational Site — San Francisco, California, United States (enrolling)
• Aligos Investigational Site — San Jose, California, United States (enrolling)
• Aligos Investigational Site — Miami, Florida, United States (enrolling)
• Aligos Investigational Site — Miami, Florida, United States (enrolling)
• Aligos Investigational Site — Marrero, Louisiana, United States (enrolling)
• Aligos Investigational Site — Baltimore, Maryland, United States (enrolling)
• Aligos Investigational Site — Chevy Chase, Maryland, United States (enrolling)
• Aligos Investigational Site — Boston, Massachusetts, United States (enrolling)
• Aligos Investigational Site — Manhasset, New York, United States (enrolling)
• Aligos Investigational Site — New York, New York, United States (enrolling)
• Aligos Investigational Site — Durham, North Carolina, United States (enrolling)
• Aligos Investigational Site — Sliven, Bulgaria (enrolling)
• Aligos Investigational Sites — Sofia, Bulgaria (enrolling)
• Aligos Investigational Site — Stara Zagora, Bulgaria (enrolling)
• Aligos Investigational Site — Edmonton, Canada (enrolling)
• Aligos Investigational Site — Ottawa, Canada (enrolling)
• Aligos Investigational Site — Toronto, Canada (enrolling)
• Aligos Investigational Sites — Vancouver, Canada (enrolling)
• Aligos Investigational Site — Chandler, Arizona, United States (enrolling)

Full record on ClinicalTrials.gov

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