Transdiagnostic Sleep and Circadian Intervention + Bright Light in Adolescents With Elevated Depression (TranS-C+BL)

Recruiting now · Not applicable

Conditions studied: Sleep Disturbance, Sleep, Depression, Suicide

In brief

The goal of this clinical trial is to adapt a sleep intervention for individuals representative of all demographic groups, including those who are at the highest risk for suicidal behavior. Sleep difficulties are a promising target for youth with suicidal thoughts and behavior to focus on as a prevention measure. We aim to increase intervention acceptability and impact by adapting it for the adolescent populations at highest risk for suicidal thoughts and behavior. The research project will compare Transdiagnostic Sleep and Circadian Intervention (TranS-C), an evidence based, modularized intervention that targets a range of sleep difficulties to a treatment as usual or control condition including providing weekly sleep feedback reports from data entered into a daily sleep diary and from wearing a sleep sensing, actigraphy watch. Participants in both conditions (TranS-C vs. Sleep Feedback) will wear an actigraphy sleep watch that monitors sleep, and complete daily sleep diaries via smartphone or email. Participants in the TranS-C condition will also wear bright light (BL) and blue blocking glasses each day as well as attend weekly or biweekly sessions with a Sleep Therapist. The sleep therapist will review sleep feedback during sessions.

Key facts

Study ID

NCT06963463

Run by

University of Pittsburgh

People needed

90

Starts

2025-05-06

Expected to finish

2027-07-31

Last updated by the study team

2026-06-04

Who can join

Age: 12 and older, up to 18. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adolescents (12-18)
• Current moderate to severe depression as measured by the PHQ-9M with a total score of greater than or equal to 11
• Current clinically significant sleep disturbance measured by the PHQ-9-M sleep item greater than or equal to 2.
• English language fluency and literacy sufficient to engage in study protocol.

You may not qualify if…

• Evidence of obstructive sleep apnea,
• Evidence of restless legs syndrome
• Evidence of psychosis
• Evidence of bipolar disorder
• Evidence of a developmental disability precluding comprehension of study procedures per electronic health record and eligibility screening.

Where it is running

• Childrens Hospital of Philadelphia — Philadelphia, Pennsylvania, United States (enrolling)
• University of Pittsburgh — Pittsburgh, Pennsylvania, United States (enrolling)

Full record on ClinicalTrials.gov

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