High-definition Surface Electromyography Markers for the Diagnosis and Monitoring of Sarcopenia
Recruiting now · Not applicable
Conditions studied: Sarcopenia
In brief
Sarcopenia is a progressive and generalised skeletal muscle disorder involving the accelerated loss of muscle mass and function that is associated with increased adverse outcomes including falls, functional decline, frailty, and mortality. In this project, the high-definition surface electromyography technology (HD-sEMG) signals will be analysed to extract features/ markers for the diagnosis of sarcopenia. This is a multicentric, descriptive, cross-sectional, parallel group study to develop a new diagnostic method. It is planned to include 846 people aged 75 years and over hospitalized in the acute geriatric or rehabilitation wards and suspected of sarcopenia (Score ≥4 on the SARC-F screening questionnaire). The inclusion duration will be 18 months and adding a 3-month patient follow-up. The total study duration will be 21 months. Patients will have their body composition using bioimpedancemetry and if possible by dual X-ray absorptiometry (DEXA). Muscular strength will be assessed by handgrip strength. Physical performance will be assessed. Additional data will be collected from their medical records.
Key facts
- Study ID
- NCT06963359
- Run by
- Assistance Publique - Hôpitaux de Paris
- People needed
- 846
- Starts
- 2025-07-09
- Expected to finish
- 2027-03-01
- Last updated by the study team
- 2026-02-13
Who can join
Age: 75 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patient aged 75 years and over
- Score ≥4 on the SARC-F screening questionnaire
- Enrolled in a social security plan (no AME)
- Informed and consenting patient
You may not qualify if…
- BMI ≥30 kg/m2
- Severe psychiatric pathology or severe cognitive disorders that do not allow the performance of examinations
- Patients who are dependent for all acts of daily life
- Patients with a very short life expectancy <3months
- Pace maker
- Recent fracture or trauma of the preventing dynamic measurement of HD-sEMG recording
- Bilateral hip prosthesis
- Skin problem that may interfere with the recording of surface EMG activity
- Skin allergies to plasters
- Allergies to electrode materials (acrylate)
- Patient under legal protection
- Patient on state medical aid (AME : Aide Médicale d'Etat)
Where it is running
- Hôpital Corentin Celton, APHP — Issy-les-Moulineaux, France (enrolling)
- Hôpital Corentin Celton, APHP — Issy-les-Moulineaux, France (enrolling)
- Hôpital Charles Foix, APHP — Ivry-sur-Seine, France (enrolling)
- Hôpital Charles Foix, APHP — Ivry-sur-Seine, France (enrolling)
- Hôpital Charles Foix, APHP — Ivry-sur-Seine, France (enrolling)
- Hôpital Tenon, APHP — Paris, France (enrolling)
- Hôpital Rothschild, APHP — Paris, France (enrolling)
- Hôpital Rothschild, APHP — Paris, France (enrolling)
- Hôpital Saint-Antoine, APHP — Paris, France (enrolling)
- Hôpital Bichat, APHP — Paris, France (enrolling)
- Unité d'Explorations fonctionnelles du sujet âgé - Hôpital Charles Foix — Ivry-sur-Seine, France
Full record on ClinicalTrials.gov
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