Novel Epigenetic Mapping in Cell-Free DNA for the Detection of Lung Cancer
Recruiting now
Conditions studied: Lung Cancer, Non-Small Cell
In brief
This trial is a multicenter, open-label, non-interventional controlled study to identify and characterize epigenetic signatures of lung cancer. The goal of this study is to develop a simple blood test that can detect lung cancer with high sensitivity, and assist in the early diagnosis and management of lung cancer. In particular, the ability to assist existing methods in cancer diagnostics, predict response to treatment, and assess the success of treatment during and after treatment will be examined. In addition, the ability to assess minimal residual disease (MRD) will be evaluated, by taking blood after surgery to remove a tumor or after treatment, and testing whether there is any residual DNA from the tumor using the markers that are found. The collection of patients and data will be conducted over a period of about a year and a half, with the aim of reaching approximately 300 participants, including patients with lung cancer before and after treatment/surgery and control groups.
Key facts
- Study ID
- NCT06963307
- Run by
- JaxBio Ltd
- People needed
- 300
- Starts
- 2025-05-01
- Expected to finish
- 2026-11-01
- Last updated by the study team
- 2025-05-09
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Men and women over 18 years old.
- Patients diagnosed with lung cancer before systemic therapy.
- Patients with inconclusive LDCT findings.
- Healthy volunteers.
- Patients with chronic lung diseases (COPD, pulmonary emphysema, acute pneumonia).
You may not qualify if…
- Subjects who did not sign a consent form.
- Patients with cancer other than lung cancer.
- Patients with HIV or hepatitis.
- Patients with active autoimmune diseases (except lung-localized diseases).
- Pregnant women or individuals unable to give informed consent.
Where it is running
- Sheba Medical Center — Ramat Gan, Israel (enrolling)
Full record on ClinicalTrials.gov
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