Thyroidectomy for Graves' Disease or Amiodarone-induced Thyrotoxicosis
Recruiting now
Conditions studied: Graves Disease, Amiodarone-Induced Thyrotoxicosis, Thyroidectomy
In brief
The goal of this observational study is to learn about the potential differences in morbidity of thyroidectomy (removal of the thyroid gland) depending on the preoperative hormonal status. The main question it aims to answer is: Do patients undergoing thyroidectomy for thyreotoxicosis (thyroid hyperfunction) due to Graves' disease or Amiodarone induced thyreotoxicosis have comparable complication rates depending on their thyroid metabolic status prior or during the procedure. The data from participants undergoing a thyroidectomy at one of the study sites will be prospectively registered in the EUROCRINE registry, including an add-on module for additional study specific routine data. The operation itself, the preoperative or postoperative treatments are not altered in any way.
Key facts
- Study ID
- NCT06963203
- Run by
- Andrea Goldmann
- People needed
- 486
- Starts
- 2025-07-01
- Expected to finish
- 2027-12-01
- Last updated by the study team
- 2025-07-02
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Adult patients (≥ 18 years of age) undergoing surgical treatment for Graves' disease or Amiodarone-induced thyrotoxicosis (AIT) with biochemically confirmed hyperthyroidism or on specific medication for the treatment of Graves' disease or AIT.
- Patients providing signed informed consent.
You may not qualify if…
- Children and minors (<18 years).
- Pregnant women.
- Patients unable or unwilling to provide informed consent due to language barriers or intellectual limitations.
- Patients undergoing concurrent parathyroidectomy for primary or secondary hyperparathyroidism, lymph node clearance, or redo surgery.
- Surgical procedures performed for other reasons than Graves' disease or AIT
Where it is running
- Spital Limmattal — Schlieren, Switzerland (enrolling)
- Universite de Lorraine, Cru Nancy — Nancy, France (enrolling)
- Evgenidion Hospital Athens — Athens, Greece (enrolling)
- Universitario Virgen de las Nieves — Granada, Spain (enrolling)
- Hospital Costa del Sol — Marbella, Spain (enrolling)
- Kantonsspital Winterthur — Zurich, Winterthur, Switzerland (enrolling)
- HOCH Kantonsspital St. Gallen — Sankt Gallen, Switzerland (enrolling)
- OLV Ziekenhuis — Aalst, Belgium (enrolling)
- Universitätsspital Bern, Inselspital — Bern, Switzerland (enrolling)
- University Hospitals of Geneva — Geneva, Switzerland (enrolling)
- University Hospital of Lausanne CHUV — Lausanne, Switzerland (enrolling)
- Spital Männedorf — Männedorf, Switzerland (enrolling)
- Ospedale Regionale di Mendrisio — Mendrisio, Switzerland (enrolling)
- Clarunis St. Clara Spital — Basel, Switzerland
- Kantonsspital Basel Land — Liestal, Switzerland
Full record on ClinicalTrials.gov
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