Test of Target Engagement of Ambiguity Aversion

Recruiting now · Not applicable

Conditions studied: Intolerance of Uncertainty, Anxiety, Intolerance of Uncertainty; Anxiety, Depression, Anxiety

In brief

The present work aims to test whether a single session intervention alters ambiguity aversion, both in terms of people's decision making and their brain responses to ambiguous choices.

Key facts

Study ID

NCT06962527

Run by

Northwestern University

People needed

140

Starts

2025-07-07

Expected to finish

2029-12-31

Last updated by the study team

2026-05-26

Who can join

Age: 25 and older, up to 60. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Ages 25 to 60
• Right-handed
• Ability to read and write English
• Capacity to provide informed consent
• Intolerance of uncertainty score ≥ -0.5 standard deviation below the mean (31st percentile)

You may not qualify if…

• Personal history of psychosis, mania, or hypomania
• Personal history of autism spectrum disorder
• IQ < 80 as determined by the Wechsler Test of Adult Reading
• Head injury with greater than 120 seconds loss of consciousness
• Neurological condition (e.g., epilepsy, Parkinson's, cerebral palsy, history of stroke)
• Currently pregnant
• Use of any implanted electrical device (e.g., pacemaker, spinal stimulator, vagal nerve stimulator, Inspire sleep apnea device, etc.).

Where it is running

• Northwestern University — Chicago, Illinois, United States (enrolling)

Full record on ClinicalTrials.gov

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