Observational Study of Platelet Dysfunction Assessed by Thromboelastography in Cardiovascular Surgery (DISPLATEG)

Recruiting now

Conditions studied: Blood Platelet Disorders, Cardiac Surgery, Postoperative Bleeding

In brief

Perioperative bleeding requiring blood transfusion is common during cardiovascular surgery, especially in procedures requiring cardiopulmonary bypass. Adenosine diphosphate (ADP) plays a fundamental role in platelet function. Several studies have shown that some patients not receiving antiplatelet therapy undergoing cardiovascular surgery have decreased platelet ADP receptor activity; the prevalence of this condition can be as high as 36%. Furthermore, extracorporeal circulation itself has been shown to cause a reduction in platelet function. Platelet dysfunction due to reduced platelet receptor activity after cardiac surgery is potentially a common cause of bleeding, perioperative blood transfusion, and surgical reexploration in patients not receiving antiplatelet agents. However, these studies are conducted with few patients and present some contradictory results, so the evidence is still scarce. The study hypothesis is that preoperative platelet dysfunction for ADP measured by TEG® Platelet Mapping™ is associated with a higher incidence of moderate-severe bleeding after CPB in patients undergoing cardiovascular surgery.

Key facts

Study ID

NCT06961175

Run by

Fundación Instituto de Estudios de Ciencias de la Salud de Castilla y León

People needed

180

Starts

2025-05-01

Expected to finish

2026-12-01

Last updated by the study team

2025-08-08

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Over 18 years of age.
• Patients undergoing elective surgery under CPB.
• Patients must be duly informed and have signed the informed consent form.
• ASA status I-IV.
• Sufficient intellectual capacity to understand the procedure.
• Normal preoperative coagulation study and platelet count.

You may not qualify if…

• Failure to meet the criteria listed above.
• Preoperative administration of antiplatelet agents with an inadequate washout period (5 days for clopidogrel and ticagrelor and 7 days for plasugrel).
• Preoperative administration of anticoagulants with an inadequate washout period.
• Thrombopenia <100,000 platelets or anemia <11 g/dL

Where it is running

• Salamanca University Hospital — Salamanca, Spain (enrolling)

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.