Linked-Color Imaging Versus Indigo Carmine Pump Spraying on the Colorectal Adenoma Detection Rate

Recruiting now · Not applicable

Conditions studied: Colonic Polyps, Adenomatous Polyps, Adenoma Detection Rate, Chromoendoscopy, Colorectal Neoplasms

In brief

Detection and removal of polyps during colonoscopy is crucial for the prevention of colorectal cancer. Indigo carmine spraying up to the colonic mucosa could probably increase the adenoma detection rate, but considering the long withdrawal time of the endoscope and the resulting increase in time and cost. Linked-color imaging (LCI) is a newly developed image-enhanced endoscopy technology. It relies on wave length optimization of three colors (red, green, and blue) to make the lesions appear fuller. LCI improves the visibility of colorectal adenomas and polyps and may increase the detection rate of lesions. In order to explore the clinical application value of Linked-color imaging endoscopy, we performed a prospective, randomized controlled trial to compare adenoma detection rate of Linked-color imaging endoscopy and indigo carmine chromoendoscopy.

Key facts

Study ID

NCT06961149

Run by

Shandong University

People needed

352

Starts

2025-04-08

Expected to finish

2026-04-01

Last updated by the study team

2025-05-07

Who can join

Age: 45 and older, up to 85. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age between 45 and 85 years
• Patients with a history of colorectal adenoma
• Patients whose first-degree relatives have a history of colorectal cancer or colorectal adenoma
• Patients with gastrointestinal symptoms (abdominal pain, bloody stool, chronic diarrhea or constipation, Unexplained anemia or weight loss;
• Patients with positive Fecal Immunochemical Test

You may not qualify if…

• Patients with pregnancy, inflammatory bowel disease, familial adenomatosis polyposis, suspected CRC; intestinal obstruction, coagulopathy
• Patients with aspirin, clopidogrel or other anticoagulants/ antiplatelet drugs intake within 7 days
• Patents previous colorectal resection
• Patients with failed cecal intubation
• Patients with inadequate bowel preparation quality (BBPS≤5)
• Patients who refuse to participate or to provide informed consent

Where it is running

• Qilu Hospital of Shandong University — Jinan, Shandong, China (enrolling)

Full record on ClinicalTrials.gov

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