Comparison of I-124 PET/CT for the Diagnosis of Thyroid Cancer
Recruiting now · Phase 2
Conditions studied: Thyroid Cancer
In brief
Persons diagnosed with thyroid cancer are often treated initially with a thyroidectomy, which is followed by ablation using Iodine-131, a therapy which has been shown to be effective and safe. Imaging of metastatic thyroid cancer has been performed with whole body I-131 and Iodine 123 (I-123) imaging for many decades and use I-123 for staging studies. Iodine 124 (I-124) is a radioisotope of iodine which emits a positron and is imaged using PET (positron emission tomography). This is a single arm prospective trial that evaluates the ability of Iodine-124 (I-124) to detect metastatic thyroid cancer compared to non-interventional, usual care I-123 and I-131 images.
Key facts
- Study ID
- NCT06961084
- Run by
- Thomas Hope
- People needed
- 62
- Starts
- 2025-12-04
- Expected to finish
- 2028-04-01
- Last updated by the study team
- 2026-06-18
Who can join
Age: 13 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age >= 13 years.
- Histopathologically confirmed differentiated or poorly differentiated thyroid cancer.
- Meeting criteria for one of the following two populations:
- American Thyroid Association (ATA) intermediate or high-risk thyroid cancer and planning on treatment using I-131.
- Metastatic disease on imaging (CT, MRI, ultrasound or FDG PET), and considering localized therapy such as surgery and radiation therapy.
- Undergone total thyroidectomy.
- Planned I-123 imaging within 45 days after enrollment.
- Ability to understand a written informed consent document, and the willingness to sign it.
You may not qualify if…
- Unlikely to comply with study procedures, restrictions and requirements and judged by the Investigator to be unsuitable for participation.
- Known pregnancy.
Where it is running
- University of California, San Francisco — San Francisco, California, United States (enrolling)
Full record on ClinicalTrials.gov
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