Mosaic Trial for Stem Cell Transplant Recipients
Recruiting now · Not applicable
Conditions studied: Hematologic Malignancy, Stem Cell Transplant, Bone Marrow Transplant, Leukemia, Lymphoma, Multiple Myeloma, Myelodysplastic Syndromes
In brief
The goal of this clinical trial is to learn if using an intervention website (Mosaic) improves selected patient-reported outcomes in adult blood cancer patients undergoing allogeneic or autologous stem cell transplant, compared to using an educational website (control group). Patients will be recruited prior to their scheduled transplant, then randomized to use one of these two study websites throughout the study. They will complete five assessments during the study: one before transplant (baseline) and four after transplant (2, 4, 6, and 8 month follow-ups). The main questions this trial aims to answer are: 1. Compared to patients using the control group website, do patients using the intervention website report greater improvements in general psychological distress, cancer treatment-related distress, physical symptoms, and health-related quality of life? 2. Are these benefits at least partially explained by improvements in perceived preparedness, self-efficacy, and approach coping and/or reductions in avoidant coping and perceived stress? 3. Do some patients benefit more from using the intervention website than others? Specifically, we will examine whether patients' primary language (English/Spanish) and their initial psychological distress are related to the benefit they get from using the intervention website. We will also explore effects of sex, race, ethnicity, and transplant type.
Key facts
- Study ID
- NCT06960993
- Run by
- Northwestern University
- People needed
- 356
- Starts
- 2025-04-28
- Expected to finish
- 2030-02-01
- Last updated by the study team
- 2026-08-03
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Diagnosed with a hematologic cancer according to medical records
- Scheduled for or preparing for scheduling of an allogeneic or autologous stem cell transplant at one of our study sites
- Aged 18 or older (no upper limit)
- English or Spanish Proficient
- Interested in using a website to learn about stem cell transplant
- Ability to understand and willingness to sign an informed consent document and comply with all study procedures
You may not qualify if…
- Currently participating in a behavioral intervention targeting distress, health-related quality of life, or symptoms
- Undergoing the first in a planned tandem stem cell transplant
- Unable to provide meaningful consent (severe cognitive impairment or language difficulties)
Where it is running
- Georgetown University School of Medicine — Washington D.C., District of Columbia, United States (enrolling)
- Northwestern University Feinberg School of Medicine — Chicago, Illinois, United States (enrolling)
- Hackensack Meridian Health — Nutley, New Jersey, United States (enrolling)
Full record on ClinicalTrials.gov
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