Effect of a Structured Physical Exercise Program on Arteriovenous Fistula Maturation for Hemodialysis in Chronic Kidney Disease Patients

Recruiting now · Not applicable

Conditions studied: Chronic Kidney Disease Requiring Hemodialysis

In brief

For patients living with Chronic Kidney Disease who are preparing to start hemodialysis, having a well-functioning arteriovenous fistula (AVF) is essential. Although the AVF is considered the best type of vascular access, its maturation process does not always go as expected-studies show that in 28% to 53% of cases, the fistula does not mature properly, making effective dialysis more difficult. There is growing interest in using physical exercise as a way to support AVF maturation. International guidelines even recommend arm exercises for this purpose. However, there is still no clear agreement on what type of exercise, how often, or how intense it should be. This study aims to evaluate whether a structured exercise program focused on the AVF arm can help improve the fistula's development and overall function.

Key facts

Study ID

NCT06960304

Run by

Unidade Local de Saúde de Coimbra, EPE

People needed

128

Starts

2025-01-16

Expected to finish

2028-12-31

Last updated by the study team

2026-07-08

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age ≥ 18 years
• AVF in the upper limb
• No cognitive decline and ability to follow instructions

You may not qualify if…

• History of previous dysfunctional ipsilateral AVF
• History of injury/condition causing pain or loss of function in the AVF limb
• Musculoskeletal conditions/osteoarticular pathology (e.g., myopathy, rheumatoid arthritis)
• Neurological conditions/cardiovascular events (e.g., stroke, peripheral neuropathy

Where it is running

• Unidade Local de Saude de Coimbra — Coimbra, Coimbra District, Portugal (enrolling)

Full record on ClinicalTrials.gov

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