Organoid-guided Personalized Treatment of Pleural Effusion
Recruiting now
Conditions studied: Lung Cancer
In brief
The study is a single-arm, single-center clinical research that utilizes patient-derived tumor organoids to predict drug sensitivity, thereby assisting clinicians in formulating treatment plans to benefit lung cancer patients with pleural effusion. This study is divided into three parts: acquisition of clinical samples from patients, in vitro organoid culture and drug sensitivity testing, and correlation of organoid sensitivity results with clinical medication guidance. Researchers obtained pre-treatment tissue samples and provided them to Suzhou Xianjue Biotechnology Co., Ltd. to establish organoid models. Once established, drug incubation was performed for sensitivity testing. Subsequently, treatment for malignant pleural effusion was guided based on drug sensitivity data.
Key facts
- Study ID
- NCT06959173
- Run by
- Henan Cancer Hospital
- People needed
- 20
- Starts
- 2025-02-21
- Expected to finish
- 2027-01-01
- Last updated by the study team
- 2025-05-06
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- (1)18 years of age and above; (2) Understand and voluntarily sign the informed consent form (ICF), and have good compliance, and can cooperate with diagnosis and follow-up; (3)ECOG score 0-2; (4) Accompanied by malignant pleural effusion; Presence of at least one measurable lesion as assessed by the investigator;
You may not qualify if…
- A history of malignant tumor in the past 5 years;
- Complicated with serious complications, such as uncontrolled heart disease, severe arrhythmia requiring medical treatment, persistent watery diarrhea, etc.;
- Pregnant or lactating female patients; Patients deemed unsuitable for participation in this study.
Where it is running
- Henan cancer hospital — Zhengzhou, Henan, China (enrolling)
Full record on ClinicalTrials.gov
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