Neuroimmunology Registry and Biobank
Recruiting now
Conditions studied: Encephalopathy, Psychosis, Impaired Consciousness, Epilepsy, Movement Disorders, Motor Neuropathy, Spasticity, Ataxia
In brief
A variety of antineuronal antibodies have been detected in the cerebrospinal fluid (CSF) of patients with neurological diseases. This raises the question of whether these antibodies are disease-specific or merely an epiphenomenon of inflammatory processes in the brain. The registry was established with the following objectives: \[1\] Are antineuronal antibodies much more common than previously thought in various neurological disorders for which the etiology has not yet been elucidated? \[2\] Can further correlations, such as those between HSV infection and NMDA receptor autoimmunity, be identified? \[3\] Are these antibodies mainly non-specific epiphenomena or are they crucial for the pathogenesis? \[4\] What is the clinical course of patients with antineuronal antibodies and their response to therapy? These questions will be addressed in a broad immunohistological screening of a large number of CSF samples and a clinical database of patients with neurological disorders.
Key facts
- Study ID
- NCT06958341
- Run by
- Charite University, Berlin, Germany
- People needed
- 300
- Starts
- 2021-02-01
- Expected to finish
- 2031-07-01
- Last updated by the study team
- 2025-05-06
Who can join
Age: any. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Differential diagnosis: suspected neuroimmunological disease in which a lumbar puncture is indicated for further diagnosis and treatment decision
- Individuals with unclear clinical diagnosis where additional CSF is to be collected for isolation of B cells and production of monoclonal antibodies. The clinical condition of the patients and his/her compliance have to allow an extra 2-3 ml of CSF to be collected.
- Age: all age groups
- Gender: patients of both sexes will be included
You may not qualify if…
- [1] Withdrawal of consent
Where it is running
- Charité - Universitätsmedizin Berlin — Berlin, State of Berlin, Germany (enrolling)
- Universität Ulm — Ulm, Germany (enrolling)
Full record on ClinicalTrials.gov
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