Reducing Dropout and Improving Outcomes From PTSD Therapy: When to Switch Therapies or Stay the Course
Recruiting now · Not applicable
Conditions studied: Post Traumatic Stress Disorder
In brief
Investigators' overall objective is to compare methods of identifying individuals who may be experiencing challenges in Cognitive Processing Therapy (CPT) and compare methods of intervening to optimize treatment retention and outcomes. Investigators' specific aims are: 1. to determine whether the use of CPT skills versus collaboratively considering switching to Present Centered Therapy (PCT) is more effective in improving outcomes for individuals experiencing challenges with CPT. Outcomes include post-traumatic stress disorder (PTSD) severity \[primary\], depression, functioning, and treatment retention; 2. to compare two approaches to identifying individuals in CPT in need of additional support during treatment; 3. to study the barriers and facilitators of implementing these intervention strategies. Finally, exploratory aims will examine the stability of differences between treatment conditions, compare combinations of interventions tested, and examine moderators of intervention effects.
Key facts
- Study ID
- NCT06957067
- Run by
- United States Department of Defense
- People needed
- 280
- Starts
- 2025-03-17
- Expected to finish
- 2028-08-31
- Last updated by the study team
- 2025-11-14
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Veterans interested in outpatient VA psychotherapy for PTSD
- Meets DSM-5 criteria for PTSD
- Be able to provide informed consent
- Be willing to be randomized
- Agree to not receive non-study psychotherapy for PTSD during study treatment (case management, supportive therapy/group, and concurrent substance use treatment are allowable)
You may not qualify if…
- Severe cognitive impairment
- Current suicidal or homicidal intent with a specific plan
- Uncontrolled psychotic or manic symptoms
- A psychiatric medication change in the past month
- A severe SUD as diagnosed by the DSM-5
Where it is running
- VA Phoenix Health Care System — Phoenix, Arizona, United States (enrolling)
- New Orleans VA Medical Center — New Orleans, Louisiana, United States (enrolling)
- Ralph H. Johnson VA Health Care System (Charleston VA) — Charleston, South Carolina, United States (enrolling)
- VA Houston Healthcare System — Houston, Texas, United States (enrolling)
Full record on ClinicalTrials.gov
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