Multiphase Optimization Strategy (MOST) for Treating Pediatric Post-traumatic Stress Disorder (PTSD)
Recruiting now · Not applicable · Has a placebo group
Conditions studied: PTSD, Trauma, Pediatric ALL
In brief
The goal of this clinical trial is to test the extent to which different treatment components work to improve pediatric post-traumatic stress disorder (PTSD). It will also provide evidence for how these components work. The main research questions are: What are the effects of different components used to treat PTSD? What do these components change to produce benefits in PTSD? Researchers will: Compare components to a psychological placebo to estimate their effects and measure how they work Examine how components work alone and in conjunction with other components Participants will: Receive different combinations of components and placebo Attend weekly treatment sessions Provide information to evaluate changes in PTSD
Key facts
- Study ID
- NCT06956781
- Run by
- University of Rochester
- People needed
- 200
- Starts
- 2026-03-15
- Expected to finish
- 2028-08-01
- Last updated by the study team
- 2026-04-08
Who can join
Age: 8 and older, up to 17. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- A child between the ages of 8-17 exposed to at least one DSM-defined trauma
- Child assent for participation
- The participation of a caregiver with custodial rights to provide parental permission
- Willing to participate in treatment delivery and respond to surveys
- Meet PTSD diagnostic criteria that is the result of exposure to at least one of the identified traumas
- Ability to read and understand English
- Willingness to be randomized to an experimental condition
- Placement in a stable caregiving environment for two months without an impending transition
- Children currently taking psychotropic medications must have taken the medicine without dose adjustment for two months prior to study entry.
- Caregiver or child with a smartphone capable of downloading a freely available software application.
You may not qualify if…
- Psychiatric concerns requiring a higher level of care (e.g. suicidal ideation with intent; current psychotic disorder)
- An intelligence quotient (IQ) < 70
- Currently receiving a behavioral health intervention for concerns related to PTSD or pediatric trauma
- A participating caregiver who is a perpetrator of any identified trauma (e.g. sexual abuse)
- MRI contraindicators (e.g. presence of metal in the body)
Where it is running
- The Mt. Hope Family Center — Rochester, New York, United States (enrolling)
Full record on ClinicalTrials.gov
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