Prophylactic TBR on Phantom Limb Pain

Enrolling by invitation · Not applicable

Conditions studied: Phantom Limb Pain After Amputation

In brief

This prospective study seeks to evaluate the effectiveness of prophylactic Targeted Brain Rehabilitation (TBR) in preventing or reducing Phantom Limb Pain (PLP).

Key facts

Study ID

NCT06956508

Run by

OrthoCarolina Research Institute, Inc.

People needed

50

Starts

2026-02-05

Expected to finish

2028-12-31

Last updated by the study team

2026-04-06

Who can join

Age: 13 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• 13+ year old patients undergoing major amputation with Dr. Gaston and Dr. Loeffler in the 12-24 months after the start of this study.
• Ability to read and comprehend English.
• Willing to use VR daily while in the inpatient setting following major amputation.

You may not qualify if…

• Patients under 12 years of age, and patients aged 13-17 without a legal guardian to give consent.
• Have used TBR extensively in the past for prior/unrelated amputation.
• Active uncontrolled mental illness
• Active neurological disease or cognitive impairment that would interfere with VR therapy or survey completion.
• Non-English speaking (surveys will only be provided in English)

Where it is running

• OrthoCarolina Research Institute — Charlotte, North Carolina, United States

Full record on ClinicalTrials.gov

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