Efferon CT Hemoadsorption for Cardiogenic Shock in Acute Myocardial Infarction
Recruiting now · Not applicable
Conditions studied: Myocardial Infarction, Cardiogenic Shock
In brief
Cardiogenic shock is the most severe manifestation of acute heart failure and remains the leading cause of death in patients hospitalised with acute myocardial infarction. Cardiogenic shock is a well-known and potent trigger of the immune response, ischemia/reperfusion organ damage, hemolysis and release of free hemoglobin. The activation of immune cells leads to the release of cytokines and inflammatory mediators such as IL-6, IL-8, activated complement and others. As a result of myocardial ischaemia and reperfusion injury, a multiorgan dysfunction syndrome may develop. The Efferon CT hemoadsorption device effectively removes cytokines and other pro-inflammatory molecules (≤55 kDa). This study evaluates whether this blood-filtering therapy can prevent organ failure in acute myocardial infarction patients with cardiogenic shock by eliminating inflammation-inducing mediators.
Key facts
- Study ID
- NCT06955936
- Run by
- Efferon JSC
- People needed
- 60
- Starts
- 2025-04-29
- Expected to finish
- 2027-07-31
- Last updated by the study team
- 2025-06-05
Who can join
Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Not more than 4 hours after diagnosis Cardiogenic shock complicating acute myocardial infarction
- Stages B - C of cardiogenic shock according to SCAI
- Patient condition allows treatment with Efferon® CT device for at least 4 hours
- SOFA score 12 or less
You may not qualify if…
- Broken-heart syndrome (takotsubo cardiomyopathy)
- Postcardiotomy cardiogenic shock
- Acute myocardial infarction within the last 4 weeks
- Myocarditis
- Cardiac trauma
- Charlson comorbidity index greater than 9 points
- Chronic kidney disease, stage 5 D (requiring continuous hemodialysis)
- Acute pulmonary embolism
- Acute cerebral circulatory collapse
- Transfusion reaction
- Patients on immunosuppressive therapy for cancer and autoimmune diseases
- Pregnancy
- Any other clinical condition of the patient that in the opinion of the investigator precludes inclusion in this study
Where it is running
- Tomsk NRMC Cardiology Research Institute — Tomsk, Russia (enrolling)
Full record on ClinicalTrials.gov
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