Early Identification of Brain Lesions in Multiple Sclerosis With Phase Sensitive Inversion Recovery MRI

Recruiting now

Conditions studied: Multiple Sclerosis

In brief

The goal of this observational study is to compare the diagnostic accuracy of Phase-Sensitive Inversion Recovery (PSIR) MRI versus conventional T2-weighted (T2W) and Fluid Attenuated Inversion Recovery (FLAIR) sequences in detecting early brain lesions in patients with Multiple Sclerosis (MS). The study will include male and female participants aged 15-65 years diagnosed with MS per the 2017 McDonald criteria. This study hypothesizes that: * PSIR MRI will detect a significantly higher number of cortical lesions (intracortical, leukocortical, and juxtacortical) compared to conventional T2W and FLAIR sequences in MS patients (p \< 0.05). * Lesions identified exclusively by PSIR will correlate more strongly with clinical measures (EDSS disability scores and SDMT cognitive performance) than those detected by T2W/FLAIR alone, suggesting PSIR's superior sensitivity to clinically relevant pathology.

Key facts

Study ID

NCT06955832

Run by

Benha University

People needed

30

Starts

2025-06-01

Expected to finish

2025-10-01

Last updated by the study team

2025-05-18

Who can join

Age: 15 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age between 15-65 years.
• Both sexes.
• Patients with MS according to McDonald Criterion

You may not qualify if…

• Age less than 15 years old.
• Patients with stroke or previous intracranial hemorrhage.
• Contraindications to MRI scans.
• MS mimics.

Where it is running

• Banha University Hospitals — Banhā, Qalyubia Governorate, Egypt (enrolling)
• El Mounira Multiple Sclerosis Unit — Cairo, Egypt (enrolling)
• Naser Institute MS Unit — Cairo, Egypt (enrolling)

Full record on ClinicalTrials.gov

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